Diagnostic and prognostic value of plasma heat shock protein 90alpha in gastric cancer
Autor: | Bang-li Hu, Kezhi Li, Yan-ping Tang, Jilin Li, Ming-zhi Xie, Xin-qiang Liang, Zhao Li, Jiang-biao Du, Yi Huang |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty T-Lymphocytes Immunology Gastroenterology Metastasis 03 medical and health sciences Tumor Biomarkers 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating Predictive Value of Tests Stomach Neoplasms Internal medicine Heat shock protein medicine Biomarkers Tumor Immunology and Allergy Humans HSP90 Heat-Shock Proteins Stage (cooking) Neoplasm Metastasis B cell Aged Neoplasm Staging Retrospective Studies Pharmacology B-Lymphocytes business.industry digestive oral and skin physiology Cancer Middle Aged medicine.disease digestive system diseases Up-Regulation 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female business |
Zdroj: | International immunopharmacology. 90 |
ISSN: | 1878-1705 |
Popis: | Background The role of plasma heat shock protein 90alpha (Hsp90α) in gastric cancers remains unclear. This study aimed to clarify the diagnostic and prognostic value of plasma Hsp90α in gastric cancer. Methods Data regarding 976 gastric cancer, 50 gastric inflammatory diseases, and 100 healthy controls were collected. Plasma Hsp90α levels in gastric cancer were compared to those in controls. Its correlation with tumor biomarkers and immune cells was examined. The association of plasma Hsp90α with clinical features and the diagnostic and prognostic value in gastric cancer were also determined. Results Plasma Hsp90α levels were remarkably increased in gastric cancer, compared to those in gastric inflammatory diseases and healthy controls. Moreover, plasma Hsp90α was correlated with CEA, CA125, CA153, CA199, T cells, Th/Ts ratio, and B cells. Plasma Hsp90α was also associated with the metastasis stage. Multivariate logistic regression analysis revealed that Hsp90α, B cells, and T cells were significantly associated with gastric cancer. Plasma Hsp90α has a moderate diagnostic value, which increased when combined with B cell, T cells. Finally, plasma Hsp90α was not associated with the survival of gastric cancer patients. Conclusion Plasma Hsp90α was elevated in gastric cancer and correlated with tumor biomarkers and immune cells. Plasma Hsp90α was associated with the metastasis stage and had moderate diagnostic performance but little prognostic value in gastric cancer. |
Databáze: | OpenAIRE |
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