Correlations between inflammatory cytokines, muscle damage markers and acute postoperative pain following primary total knee arthroplasty
| Autor: | Yi Zeng, Jing-qiu Cheng, Fuxing Pei, Bin Shen, Ti-min Yang, Haibo Si, Zongke Zhou, Yanrong Lu |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Sports medicine Analgesic Gastroenterology Muscle damage markers Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Synovial fluid Orthopedics and Sports Medicine Arthroplasty Replacement Knee Muscle Skeletal Body mass index Aged Pain Measurement Acute postoperative pain Pain Postoperative 030222 orthopedics business.industry Middle Aged Inflammatory cytokines Acute Pain Surgery Knee pain Total knee arthroplasty Orthopedic surgery Cytokines Female Inflammation Mediators lcsh:RC925-935 medicine.symptom business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Musculoskeletal Disorders, Vol 18, Iss 1, Pp 1-9 (2017) BMC Musculoskeletal Disorders |
| ISSN: | 1471-2474 |
| DOI: | 10.1186/s12891-017-1597-y |
| Popis: | Background Despite the success of total knee arthroplasty (TKA) in reducing knee pain and improving functional disability, the management of acute postoperative pain is still unsatisfactory. This study was aimed to quantitatively analyze the possible correlations between inflammatory cytokines, muscle damage markers and acute postoperative pain following primary TKA. Methods Patients scheduled for unilateral primary TKA were consecutively included, the serial changes of the numerical rating scale (NRS) at rest (NRSR) and at walking (NRSW), serum inflammatory cytokines and muscle damage markers were assessed before surgery (T0) and at postoperative day 1, 2, 3 and 5 (T1-T4, respectively); while pain disability questionnaire (PDQ) and synovial fluid inflammatory cytokines were evaluated at T0. The correlations between inflammatory cytokines, muscle damage markers and pain scores were examined, and Bonferroni correction was applied for multiple comparisons. Results Ninety six patients were included for serum markers and pain evaluations at T0-T4, while 54 (56.25%) for synovial fluid cytokines at T0. The NRSR at T1 and T2 were positively correlated with preoperative NRSW, while the NRSW at T1 to T4 were positively correlated with preoperative NRSR, NRSW and PDQ (all p |
| Databáze: | OpenAIRE |
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