Glycerophosphate-based chitosan thermosensitive hydrogels and their biomedical applications
| Autor: | Jun Bo Li, Ling Juan Jiang, Xiguang Chen, Hui Yun Zhou, Pei Pei Cao |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Chitosan Polymers and Plastics Tissue Engineering Organic Chemistry technology industry and agriculture Temperature Hydrogels macromolecular substances Polysaccharide Biocompatible material carbohydrates (lipids) chemistry.chemical_compound Drug Delivery Systems chemistry Chitin Chemical engineering Tissue engineering Glucosamine Glycerophosphates Polymer chemistry Self-healing hydrogels Drug delivery Materials Chemistry |
| Zdroj: | Carbohydrate polymers. 117 |
| ISSN: | 1879-1344 |
| Popis: | Chitosan is non-toxic, biocompatible and biodegradable polysaccharide composed of glucosamine and derived by deacetylation of chitin. Chitosan thermosensitive hydrogel has been developed to form a gel in situ, precluding the need for surgical implantation. In this review, the recent advances in chitosan thermosensitive hydrogels based on different glycerophosphate are summarized. The hydrogel is prepared with chitosan and β-glycerophosphate or αβ-glycerophosphate which is liquid at room temperature and transits into gel as temperature increases. The gelation mechanism may involve multiple interactions between chitosan, glycerophosphate, and water. The solution behavior, rheological and physicochemical properties, and gelation process of the hydrogel are affected not only by the molecule weight, deacetylation degree, and concentration of chitosan, but also by the kind and concentration of glycerophosphate. The properties and the three-dimensional networks of the hydrogel offer them wide applications in biomedical field including local drug delivery and tissue engineering. |
| Databáze: | OpenAIRE |
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