| Autor: |
Yu Zhao, Ping Wu, Jianjun Wu, Matthias Brendel, Jiaying Lu, Jingjie Ge, Chunmeng Tang, Jimin Hong, Qian Xu, Fengtao Liu, Yimin Sun, Zizhao Ju, Huamei Lin, Yihui Guan, Claudio Bassetti, Markus Schwaiger, Sung-Cheng Huang, Axel Rominger, Jian Wang, Chuantao Zuo, Kuangyu Shi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Zhao, Yu; Wu, Ping; Wu, Jianjun; Brendel, Matthias; Lu, Jiaying; Ge, Jingjie; Tang, Chunmeng; Hong, Jimin; Xu, Qian; Liu, Fengtao; Sun, Yimin; Ju, Zizhao; Lin, Huamei; Guan, Yihui; Bassetti, Claudio; Schwaiger, Markus; Huang, Sung-Cheng; Rominger, Axel; Wang, Jian; Zuo, Chuantao; ... (2022). Decoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning. European journal of nuclear medicine and molecular imaging, 49(8), pp. 2798-2811. Springer 10.1007/s00259-022-05804-x |
| DOI: |
10.1007/s00259-022-05804-x |
| Popis: |
Purpose This work attempts to decode the discriminative information in dopamine transporter (DAT) imaging using deep learning for the differential diagnosis of parkinsonism. Methods This study involved 1017 subjects who underwent DAT PET imaging ([11C]CFT) including 43 healthy subjects and 974 parkinsonian patients with idiopathic Parkinson’s disease (IPD), multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). We developed a 3D deep convolutional neural network to learn distinguishable DAT features for the differential diagnosis of parkinsonism. A full-gradient saliency map approach was employed to investigate the functional basis related to the decision mechanism of the network. Furthermore, deep-learning-guided radiomics features and quantitative analysis were compared with their conventional counterparts to further interpret the performance of deep learning. Results The proposed network achieved area under the curve of 0.953 (sensitivity 87.7%, specificity 93.2%), 0.948 (sensitivity 93.7%, specificity 97.5%), and 0.900 (sensitivity 81.5%, specificity 93.7%) in the cross-validation, together with sensitivity of 90.7%, 84.1%, 78.6% and specificity of 88.4%, 97.5% 93.3% in the blind test for the differential diagnosis of IPD, MSA and PSP, respectively. The saliency map demonstrated the most contributed areas determining the diagnosis located at parkinsonism-related regions, e.g., putamen, caudate and midbrain. The deep-learning-guided binding ratios showed significant differences among IPD, MSA and PSP groups (P P = 0.24 and P = 0.30). Furthermore, compared to conventional radiomics features, there existed average above 78.1% more deep-learning-guided radiomics features that had significant differences among IPD, MSA and PSP. Conclusion This study suggested the developed deep neural network can decode in-depth information from DAT and showed potential to assist the differential diagnosis of parkinsonism. The functional regions supporting the diagnosis decision were generally consistent with known parkinsonian pathology but provided more specific guidance for feature selection and quantitative analysis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
