Acute fat loss does not affect bone mass
| Autor: | Jianyao Wu, Juha Tuukkanen, Klara Sjögren, Karin Gustafsson, Louise Grahnemo, Helen H. Farman, Ingrid Wernstedt Asterholm, Antti Koskela, Petra Henning, Claes Ohlsson, Marie K Lagerquist |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Science Adipose tissue Apoptosis Bone Marrow Cells Mice Transgenic 030209 endocrinology & metabolism Caspase 8 Adipocyte apoptosis Bone and Bones Article 03 medical and health sciences 0302 clinical medicine Internal medicine Adipocytes medicine Animals Lymphocyte Count Bone Adiposity Multidisciplinary Adipose tissue loss business.industry Organ Size medicine.disease Metabolic syndrome Obesity Biomechanical Phenomena Experimental models of disease 030104 developmental biology Endocrinology Medicine Bone Remodeling business Fat loss Body mass index Biomarkers Spleen Bone mass |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Obesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent studies suggest that increased adiposity negatively impacts bone mass. Here, we aimed to test whether acute loss of adipose tissue, via adipocyte apoptosis, alters bone mass in age-related obese mice. Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20187 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was administered to 5.5 month-old mice that were terminated 2 weeks later. At termination, the total fat mass weighed 58% less in dimerizer-treated mice compared with vehicle-treated controls, but bone mass did not differ. To allow for the detection of long-term effects, we used 9-month-old mice that were terminated six weeks after dimerizer administration. In this experiment, the total fat mass weighed less (− 68%) in the dimerizer-treated mice than in the controls, yet neither bone mass nor biomechanical properties differed between groups. Our findings show that adipose tissue loss, despite the reduced mechanical loading, does not affect bone in age-related obese mice. Future studies are needed to test whether adipose tissue loss is beneficial during more severe obesity. |
| Databáze: | OpenAIRE |
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