Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer:A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition

Autor: Kim Overvad, Elio Riboli, Krasimira Aleksandrova, Nicholas J. Wareham, Domenico Palli, Rosario Tumino, Miren Dorronsoro, Rudolf Kaaks, Valeria Pala, Petra H.M. Peeters, Françoise Clavel-Chapelon, Kay-Tee Khaw, María José Sánchez, Fränzel J.B. Van Duijnhoven, Francesca L. Crowe, Eva Ardanaz, Tobias Pischon, Anja Olsen, Veronika Fedirko, Peter D. Siersema, Heiner Boeing, Mazda Jenab, Paolo Vineis, Anne Tjønneland, José María Huerta, Annekatrin Lukanova, Sophie Morois, H. Bas Bueno-de-Mesquita, Dimitrios Trichopoulos, Teresa Norat, Carlos González, Göran Hallmans, Richard Palmqvist, Vardis Dilis, Eugene Jansen, Antonia Trichopoulou, Salvatore Panico, Sjoukje H.S. Woudt, Anke M. Leufkens, Guri Skeie, Naomi E. Allen, Marie-Christine Boutron-Ruault, Marcial Argüelles
Přispěvatelé: Leufkens, Am, van Duijnhoven, Fj, Woudt, Sh, Siersema, Pd, Jenab, M, Jansen, Eh, Pischon, T, Tj?nneland, A, Olsen, A, Overvad, K, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, Salvatore, Kaaks, R, Lukanova, A, Boeing, H, Aleksandrova, K, Trichopoulou, A, Trichopoulos, D, Dilis, V, Peeters, Ph, Skeie, G, Gonz?lez, Ca, Arg?elles, M, S?nchez, Mj, Dorronsoro, M, Huerta, Jm, Ardanaz, E, Hallmans, G, Palmqvist, R, Khaw, Kt, Wareham, N, Allen, Ne, Crowe, Fl, Fedirko, V, Norat, T, Riboli, E, Bueno de Mesquita, Hb
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Leufkens, A M, van Duijnhoven, F J B, Woudt, S H S, Siersema, P D, Jenab, M, Jansen, E H J M, Pischon, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M C, Clavel-Chapelon, F, Morois, S, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Lukanova, A, Boeing, H, Aleksandrova, K, Trichopoulou, A, Trichopoulos, D, Dilis, V, Peeters, P H, Skeie, G, González, C A, Argüelles, M, Sánchez, M-J, Dorronsoro, M, Huerta, J M, Ardanaz, E, Hallmans, G, Palmqvist, R, Khaw, K-T, Wareham, N, Allen, N E, Crowe, F L, Fedirko, V, Norat, T, Riboli, E & Bueno-de-Mesquita, H B 2012, ' Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer : A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition ', American Journal of Epidemiology, vol. 175, no. 7, pp. 653-63 . https://doi.org/10.1093/aje/kwr418
Popis: Oxidative stress has been shown to play an important role in carcinogenesis, but prospective evidence for an association between biomarkers of oxidative stress and colorectal cancer (CRC) risk is limited. The authors investigated the association between prediagnostic serum levels of oxidative stress indicators (i.e., reactive oxygen metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC risk. This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95% confidence intervals were calculated using conditional logistic regression analyses. ROM were associated with overall CRC risk (highest tertile vs. lowest: adjusted incidence rate ratio (IRR(adj)) = 1.91, 95% confidence interval (CI): 1.47, 2.48), proximal (IRR(adj) = 1.89, 95% CI: 1.06, 3.36) and distal (IRR(adj) = 2.31, 95% CI: 1.37, 3.89) colon cancer, and rectal cancer (IRR(adj) = 1.69, 95% CI: 1.05, 2.72). When results were stratified by tertile of follow-up time, the association remained significant only in participants with less than 2.63 years of follow-up (IRR(adj) = 2.28, 95% CI: 1.78, 2.94; P-heterogeneity < 0.01). FRAP was not associated with CRC risk. In conclusion, prediagnostic serum ROM levels were associated with increased risk of CRC. However, this association was seen only in subjects with relatively short follow-up, suggesting that the association results from production of reactive oxygen species by preclinical tumors.
Databáze: OpenAIRE
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