Sex-related differences in patients with coronavirus disease 2019: Results of the Cardio-COVID-Italy multicentre study
| Autor: | Carlo Mario Lombardi, Claudia Specchia, Fabio Conforti, Maria Teresa La Rovere, Valentina Carubelli, Piergiuseppe Agostoni, Stefano Carugo, Gian Battista Danzi, Marco Guazzi, Andrea Mortara, Massimo Piepoli, Italo Porto, Gianfranco Sinagra, Maurizio Volterrani, Pietro Ameri, Massimiliano Gnecchi, Sergio Leonardi, Marco Merlo, Annamaria Iorio, Antonio Bellasi, Claudia Canale, Rita Camporotondo, Francesco Catagnano, Laura Adelaide Dalla Vecchia, Mattia Di Pasquale, Stefano Giovinazzo, Gloria Maccagni, Massimo Mapelli, Davide Margonato, Luca Monzo, Vincenzo Nuzzi, Chiara Oriecuia, Laura Pala, Giulia Peveri, Andrea Pozzi, Giovanni Provenzale, Filippo Sarullo, Marianna Adamo, Daniela Tomasoni, Riccardo Maria Inciardi, Michele Senni, Marco Metra |
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| Přispěvatelé: | Lombardi, C, Specchia, C, Conforti, F, Rovere, M, Carubelli, V, Agostoni, P, Carugo, S, Danzi, G, Guazzi, M, Mortara, A, Piepoli, M, Porto, I, Sinagra, G, Volterrani, M, Ameri, P, Gnecchi, M, Leonardi, S, Merlo, M, Iorio, A, Bellasi, A, Canale, C, Camporotondo, R, Catagnano, F, Dalla Vecchia, L, Di Pasquale, M, Giovinazzo, S, Maccagni, G, Mapelli, M, Margonato, D, Monzo, L, Nuzzi, V, Oriecuia, C, Pala, L, Peveri, G, Pozzi, A, Provenzale, G, Sarullo, F, Adamo, M, Tomasoni, D, Inciardi, R, Senni, M, Metra, M, Lombardi, C. M., Specchia, C., Conforti, F., Rovere, M. T., Carubelli, V., Agostoni, P., Carugo, S., Danzi, G. B., Guazzi, M., Mortara, A., Piepoli, M., Porto, I., Sinagra, G., Volterrani, M., Ameri, P., Gnecchi, M., Leonardi, S., Merlo, M., Iorio, A., Bellasi, A., Canale, C., Camporotondo, R., Catagnano, F., Dalla Vecchia, L. A., Di Pasquale, M., Giovinazzo, S., Maccagni, G., Mapelli, M., Margonato, D., Monzo, L., Nuzzi, V., Oriecuia, C., Pala, L., Peveri, G., Pozzi, A., Provenzale, G., Sarullo, F., Adamo, M., Tomasoni, D., Inciardi, R. M., Senni, M., Metra, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Popis: | INTRODUCTION: The role of sex compared to comorbidities and other prognostic variables in patients with coronavirus disease (COVID-19) is unclear. METHODS: This is a retrospective observational study on patients with COVID-19 infection, referred to 13 cardiology units. The primary objective was to assess the difference in risk of death between the sexes. The secondary objective was to explore sex-based heterogeneity in the association between demographic, clinical and laboratory variables, and patients' risk of death. RESULTS: Seven hundred and one patients were included: 214 (30.5%) women and 487 (69.5%) men. During a median follow-up of 15 days, deaths occurred in 39 (18.2%) women and 126 (25.9%) men. In a multivariable Cox regression model, men had a nonsignificantly higher risk of death vs. women (P = 0.07).The risk of death was more than double in men with a low lymphocytes count as compared with men with a high lymphocytes count [overall survival hazard ratio (OS-HR) 2.56, 95% confidence interval (CI) 1.72-3.81]. In contrast, lymphocytes count was not related to death in women (P = 0.03).Platelets count was associated with better outcome in men (OS-HR for increase of 50 × 103 units: 0.88 95% CI 0.78-1.00) but not in women. The strength of association between higher PaO2/FiO2 ratio and lower risk of death was larger in women (OS-HR for increase of 50 mmHg/%: 0.72, 95% CI 0.59-0.89) vs. men (OS-HR: 0.88, 95% CI 0.80-0.98; P = 0.05). CONCLUSIONS: Patients' sex is a relevant variable that should be taken into account when evaluating risk of death from COVID-19. There is a sex-based heterogeneity in the association between baseline variables and patients' risk of death. |
| Databáze: | OpenAIRE |
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