Interaction Between Dietary Lipids and Physical Inactivity on Insulin Sensitivity and on Intramyocellular Lipids in Healthy Men
| Autor: | Michael Ith, Christophe Binnert, Chris Boesch, Rodrigue Stettler, Kevin J. Acheson, Luc Tappy, Jacques Décombaz |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Saturated fat Dietary lipid Motor Activity Insulin resistance Internal medicine Diabetes mellitus Dietary Carbohydrates Internal Medicine medicine Humans Insulin Intramyocellular lipids Life Style Pancreatic hormone Advanced and Specialized Nursing business.industry Glucose clamp technique medicine.disease Dietary Fats Endocrinology Physical Fitness Glucose Clamp Technique business |
| Zdroj: | Diabetes Care. 28:1404-1409 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE—To assess the effect of a possible interaction between dietary fat and physical inactivity on whole-body insulin sensitivity and intramyocellular lipids (IMCLs). RESEARCH DESIGN AND METHODS—Eight healthy male volunteers were studied on two occasions. After 2 days of an equilibrated diet and moderate physical activity, participants remained inactive (bed rest) for 60 h and consumed either a high–saturated fat (45% fat, of which ∼60% was saturated fat [BR-HF]) or a high-carbohydrate (70% carbohydrate [BR-HCHO]) diet. To evaluate the effect of a high-fat diet alone, six of the eight volunteers were restudied after a 2-day equilibrated diet followed by 60 h on a high–saturated fat diet and controlled physical activity (PA-HF). Insulin sensitivity was measured by hyperinsulinemic-euglycemic clamp and IMCL concentrations by 1H-magnetic resonance spectroscopy. RESULTS—Insulin-mediated glucose disposal was decreased by BR-HF condition (−24 ± 6%, P < 0.05) but did not change with BR-HCHO (+19 ± 10%, NS). BR-HF and BR-HCHO increased IMCL levels (+32 ± 7%, P < 0.05 and +17 ± 8%, P < 0.0011, respectively). Although the increase in IMCL levels with PA-HF (+31 ± 19%, P = 0.12) was similar to that during BR-HF, insulin-mediated glucose disposal (−7 ± 9%, NS) was not decreased. CONCLUSIONS—These data indicate that physical inactivity and a high–saturated fat diet may interact to reduce whole-body insulin sensitivity. IMCL content was influenced by dietary lipid and physical inactivity but was not directly associated with insulin resistance. |
| Databáze: | OpenAIRE |
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