Mechanical force induces mitochondrial fission
| Autor: | Afshin Vahid, Anđela Šarić, Luca Hirt, Tomaso Zambelli, Mathias J. Aebersold, Jess G. Snedeker, Benoît Kornmann, Raphael R Grüter, Timon Idema, Serge Mostowy, Qian Feng, Sebastian Carsten Johannes Helle, Andrea Sirianni |
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| Přispěvatelé: | University of Zurich, Kornmann, Benoît |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fission QH301-705.5 Structural Biology and Molecular Biophysics Science Cytological Techniques 610 Medicine & health Mitochondrion Mitochondrial Dynamics General Biochemistry Genetics and Molecular Biology Cell Line 03 medical and health sciences DNM1L 0302 clinical medicine 1300 General Biochemistry Genetics and Molecular Biology 2400 General Immunology and Microbiology Chlorocebus aethiops Organelle Animals Humans fission drp1 Biology (General) Actin mff General Immunology and Microbiology General Neuroscience 2800 General Neuroscience Cell Biology General Medicine mechanobiology mitochondria 030104 developmental biology Cytoplasm Membrane curvature Biophysics Medicine Mitochondrial fission 10046 Balgrist University Hospital Swiss Spinal Cord Injury Center Stress Mechanical force 030217 neurology & neurosurgery Research Article Human |
| Zdroj: | eLife, Vol 6 (2017) eLife, 6 eLife |
| ISSN: | 2050-084X |
| Popis: | Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria – via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces – results in the recruitment of the mitochondrial fission machinery, and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites. Thus, mitochondria adapt to the environment by sensing and responding to biomechanical cues. Our findings that mechanical triggers can be coupled to biochemical responses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm. eLife, 6 ISSN:2050-084X |
| Databáze: | OpenAIRE |
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