Neuromuscular rehabilitation by treadmill running or electrical stimulation after peripheral nerve injury and repair
| Autor: | Tanguy Marqueste, Yves Jammes, Olivier Alluin, Patrick Decherchi, Jean-Roch Alliez |
|---|---|
| Přispěvatelé: | Laboratoire des Déterminants Physiologiques de l'Activité Physique, Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiopathologie Respiratoire (UPRES EA 2201), Université de la Méditerranée - Aix-Marseille 2-Institut Fédératif de Recherches Jean ROCHE (IFR 11)-Faculté de Médecine Nord, Khrestchatisky, Michel, Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2 |
| Rok vydání: | 2004 |
| Předmět: |
MESH: Nerve Regeneration
Physiology MESH: Organ Size MESH: Muscle Contraction Action Potentials Stimulation MESH: Rats Sprague-Dawley Potassium Chloride Rats Sprague-Dawley Tendons 0302 clinical medicine Tibialis anterior muscle Peripheral Nerve Injuries MESH: Animals MESH: Action Potentials MESH: Muscle Skeletal 0303 health sciences MESH: Neurons Afferent MESH: Electric Stimulation Organ Size Anatomy MESH: Tendons MESH: Motor Activity medicine.anatomical_structure MESH: Muscle Fatigue Anesthesia Muscle Fatigue Peripheral nerve injury Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.symptom Muscle Contraction Muscle contraction MESH: Axons MESH: Rats Neuromuscular Junction Motor Activity Vibration Neuromuscular junction Injections Lesion 03 medical and health sciences Physiology (medical) medicine Animals MESH: Injections Lactic Acid Neurons Afferent [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Muscle Skeletal 030304 developmental biology Wound Healing MESH: Vibration Muscle fatigue business.industry Nerve injury MESH: Peripheral Nerves Axons Electric Stimulation Nerve Regeneration Rats MESH: Wound Healing MESH: Wounds and Injuries MESH: Potassium Chloride Wounds and Injuries MESH: Lactic Acid MESH: Neuromuscular Junction business MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Journal of Applied Physiology Journal of Applied Physiology, American Physiological Society, 2004, 96 (5), pp.1988-95. ⟨10.1152/japplphysiol.00775.2003⟩ Journal of Applied Physiology, American Physiological Society, 2004, 96(5), pp.1988-1995 Journal of Applied Physiology, 2004, 96 (5), pp.1988-95. ⟨10.1152/japplphysiol.00775.2003⟩ Journal of Applied Physiology, 2004, 96(5), pp.1988-1995 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00775.2003 |
| Popis: | Numerous studies have been devoted to the regeneration of the motor pathway toward a denervated muscle after nerve injury. However, the regeneration of sensory muscle endings after repair by self-anastomosis are little studied. In previous electrophysiological studies, our laboratory showed that the functional characteristics of tibialis anterior muscle afferents are differentially affected after injury and repair of the peroneal nerve with and without chronic electrostimulation. The present study focuses on the axonal regeneration of mechano- (fibers I and II) and metabosensitive (fibers III and IV) muscle afferents by evaluating the recovery of their response to different test agents after nerve injury and repair by self-anastomosis during 10 wk of treadmill running (LSR). Data were compared with control animals (C), animals with nerve lesion and suture (LS), and animals with lesion, suture, and chronic muscle rehabilitation by electrostimulation (LSE) with a biphasic current modulated in pulse duration and frequency, eliciting a pattern mimicking the activity delivered by the nerve to the muscle. Compared with the C group, results indicated that 1) muscle weight was smaller in LS and LSR groups, 2) the fatigue index was greater in the LS group and smaller in the LSE group, 3) metabosensibility remained altered in the LS and LSE groups, and 4) mechanosensitivity presented a large increase of the activation pattern in the LS and LSE groups. Our data indicated that chronic muscle electrostimulation partially favors the recovery of muscle properties (i.e., muscle weight and twitch response were close to the C group) and that rehabilitation by treadmill running also efficiently induced a better functional muscle afferent recovery (i.e., the discharge pattern was similar to the C group). The effectiveness of the chronic electromyostimulation and the treadmill exercise on afferent recovery is discussed with regard to parameters listed above. |
| Databáze: | OpenAIRE |
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