Sexual transmission of american trypanosomes from males and females to naive mates
| Autor: | Francisco Ernesto Moreno Bernal, Ana de Cássia Rosa, Antonio R. L. Teixeira, Sebastião Aldo da Silva Valente, Perla F. Araujo, Adriana B. Almeida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Chagas disease Sexual transmission Offspring Transmiss?o Vertical de Doen?a Infecciosa Trypanosoma cruzi General Chemical Engineering Doen?a de Chagas / parasitologia Doen?a de Chagas / imunologia Population Sexually Transmitted Diseases Physiology Semen Chick Embryo General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine Animals Humans Chagas Disease education education.field_of_study Doen?a de Chagas / transmiss?o General Immunology and Microbiology biology General Neuroscience Chagas Doença de biology.organism_classification Epididymis medicine.disease 030104 developmental biology Seminiferous tubule medicine.anatomical_structure 030220 oncology & carcinogenesis Tripanossoma cruzi Female |
| Zdroj: | Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| Popis: | Foundation for the Advancement of Science (FAPDF) ; National Research Council, Ministry of Science and Technology (CNPq/MCT) ; Agency for Training Human Resources, Ministry of Education (CAPES/ME), Brazil . Universidade de Brasilia. Faculdade de Medicina. Multidisciplinar de Pesquisa em Doen?as de Chagas. Brasilia, DF, Brazil. Universidade de Brasilia. Faculdade de Medicina. Multidisciplinar de Pesquisa em Doen?as de Chagas. Brasilia, DF, Brazil. Universidade de Brasilia. Faculdade de Medicina. Multidisciplinar de Pesquisa em Doen?as de Chagas. Brasilia, DF, Brazil. Universidade de Brasilia. Faculdade de Medicina. Multidisciplinar de Pesquisa em Doen?as de Chagas. Brasilia, DF, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Universidade de Brasilia. Faculdade de Medicina. Multidisciplinar de Pesquisa em Doen?as de Chagas. Brasilia, DF, Brazil. American trypanosomiasis is transmitted to humans by triatomine bugs through the ingestion of contaminated food, by blood transfusions or accidently in hospitals and research laboratories. In addition, the Trypanosoma cruzi infection is transmitted congenitally from a chagasic mother to her offspring, but the male partner's contribution to in utero contamination is unknown. The findings of nests and clumps of amastigotes and of trypomastigotes in the theca cells of the ovary, in the goniablasts and in the lumen of seminiferous tubules suggest that T. cruzi infections are sexually transmitted. The research protocol herein presents the results of a family study population showing parasite nuclear DNA in the diploid blood mononuclear cells and in the haploid gametes of human subjects. Thus, three independent biological samples collected one year apart confirmed that T. cruzi infections were sexually transmitted to progeny. Interestingly, the specific T. cruzi antibody was absent in the majority of family progeny that bore immune tolerance to the parasite antigen. Immune tolerance was demonstrated in chicken refractory to T. cruzi after the first week of embryonic growth, and chicks hatched from the flagellate-inoculated eggs were unable to produce the specific antibody. Moreover, the instillation of the human semen ejaculates intraperitoneally or into the vagina of naive mice yielded T. cruzi amastigotes in the epididymis, seminiferous tubule, vas deferens and uterine tube with an absence of inflammatory reactions in the immune privileged organs of reproduction. The breeding of T. cruzi-infected male and female mice with naive mates resulted in acquisition of the infections, which were later transmitted to the progeny. Therefore, a robust education, information and communication program that involves the population and social organizations is deemed necessary to prevent Chagas disease. |
| Databáze: | OpenAIRE |
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