Psychiatric Disturbances Associated with Ganciclovir Therapy
| Autor: | Joseph M. Brocavich, Julie L. Chen, Anne Y.F. Lin |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Ganciclovir Hallucinations Exacerbation viruses Neurocognitive Disorders 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Psychiatric history medicine Haloperidol Humans Pharmacology (medical) 030212 general & internal medicine Acquired Immunodeficiency Syndrome Maintenance dose business.industry Retinitis virus diseases Middle Aged medicine.disease Dreams Regimen Anesthesia Cytomegalovirus Infections Injections Intravenous Female Kidney Diseases Psychiatric disturbances Cytomegalovirus retinitis business medicine.drug |
| Zdroj: | Annals of Pharmacotherapy. 26:193-195 |
| ISSN: | 1542-6270 1060-0280 |
| Popis: | OBJECTIVE: To report a case of possible ganciclovir-induced psychiatric disturbances. CASE SUMMARY: A patient with AIDS who had no known psychiatric history and mild renal dysfunction experienced exacerbation of cytomegalovirus retinitis and was treated with ganciclovir 5 mg/kg iv q12h. The patient complained of nightmares and developed visual hallucinations and severe agitation on day 15 of ganciclovir therapy. The problems resolved after haloperidol administration and ganciclovir withdrawal and reappeared when the same regimen was reinstituted. However, the patient was able to tolerate the maintenance dose of ganciclovir at 5 mg/kg/d along with haloperidol later without further episodes of visual hallucinations. DISCUSSION: Case reports in the literature on ganciclovir- or its analog, acyclovir-, induced psychiatric disturbances were reviewed and compared. The potential relationship between ganciclovir accumulation in patients with renal insufficiency and the observed central nervous system problems in our patient was postulated. CONCLUSIONS: It is likely that ganciclovir accumulation contributed to the acute psychotic episodes observed in our patient. Adjusting ganciclovir dosage based on the patient's renal function is probably the only approach required to prevent or reduce the incidence of these episodes. |
| Databáze: | OpenAIRE |
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