Incidence and risk factors for urinary tract infections in the first year after renal transplantation
| Autor: | Ebru Asicioglu, Gokhan Guneri, Arzu Velioglu, Yiloren Tanidir, Serhan Tuglular, Hakki Arikan, Cumhur Yegen, Ilker Tinay, Elif Tukenmez Tigen |
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| Přispěvatelé: | Velioglu, Arzu, Guneri, Gokhan, Arikan, Hakki, Asicioglu, Ebru, Tigen, Elif Tukenmez, Tanidir, Yiloren, Tinay, Ilker, Yegen, Cumhur, Tuglular, Serhan |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Antibiotics 030230 surgery Pathology and Laboratory Medicine 0302 clinical medicine Risk Factors Medicine and Health Sciences Renal Transplantation EPIDEMIOLOGY Medicine Infection control Escherichia coli Infections Escherichia Coli Multidisciplinary Antimicrobials Incidence Incidence (epidemiology) Graft Survival Drugs Middle Aged Immunosuppressives Anti-Bacterial Agents Bacterial Pathogens Klebsiella pneumoniae Experimental Organism Systems Medical Microbiology Urinary Tract Infections BACTERIA Engineering and Technology Prokaryotic Models Female Pathogens Research Article Biotechnology Adult Escherichia medicine.medical_specialty Catheters KIDNEY-TRANSPLANTATION medicine.drug_class Urology Science Urinary system 030106 microbiology Surgical and Invasive Medical Procedures Bioengineering Research and Analysis Methods Microbiology beta-Lactamases Urinary System Procedures 03 medical and health sciences Model Organisms Antibiotic resistance Enterobacteriaceae Microbial Control Diabetes mellitus Internal medicine Humans Microbial Pathogens Retrospective Studies Pharmacology Transplantation Genitourinary Infections business.industry Gut Bacteria Organisms Biology and Life Sciences Organ Transplantation medicine.disease Kidney Transplantation Confidence interval Klebsiella Infections RECIPIENTS Medical Risk Factors Antibiotic Resistance Animal Studies Medical Devices and Equipment Antimicrobial Resistance business |
| Zdroj: | PLoS ONE, Vol 16, Iss 5, p e0251036 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0251036 |
| Popis: | Background The most common infections among renal transplant patients are urinary tract infections (UTI). Our main objective in this study is to determine the incidence of UTIs in patients who have undergone renal transplantation in our hospital, to identify the causative microbiological agents, risk factors and determine the effects of UTI on short-term graft survival. Methods Urinary tract infections, which developed within the first year of renal transplantation, were investigated. Patients were compared regarding demographic, clinical, laboratory characteristics and graft survival. Results 102 patients were included in our study. Fifty-three patients (53%) were male and 49 (48%) were female. Sixty-seven urinary tract infection attacks in 21 patients (20.5%) were recorded. Age (p = 0.004; 95% Confidence Interval [CI]: 1.032–1.184), longer indwelling urinary catheter stay time (p = 0.039; 95% Confidence Interval [CI]: 1.013–1.661) and urologic complications (p = 0.006; 95% Confidence Interval [CI]: 0.001–0.320) were found as risk factors for UTI development in the first year of transplantation. Escherichia coli and Klebsiella pneumoniae were the most frequently isolated microorganisms. Of these bacteria, 63.2% were found to be extended spectrum beta lactamase (ESBL) positive. Multidrug resistant microorganisms (MDROs) were more frequent in male patients (32 episodes in males vs. 14 episodes in females, p = Conclusion Our study results represent the high incidence of UTI with MDROs in KT recipients. Infection control methods should be applied even more vigorously especially in male transplant patients since a higher incidence of UTI caused by resistant microorganisms was reported in male patients. |
| Databáze: | OpenAIRE |
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