Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis
| Autor: | Rhonda Rogers, Nana Maeda, Simon J. Conway, Andrew Lindsley, Wei Li, Jian Wang |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
DNA
Complementary Time Factors Cell Adhesion Molecules Neuronal Morphogenesis Clone (cell biology) Periostin Biology Mice Transforming Growth Factor beta Cell Adhesion Heart Septum Genetics Animals Molecular Biology Gene In Situ Hybridization Phylogeny Extracellular Matrix Proteins Cell adhesion molecule Myocardium Gene Expression Regulation Developmental Anatomy Blotting Northern Heart Valves Immunohistochemistry Transmembrane protein Protein Structure Tertiary Cell biology cardiovascular system Atrioventricular canal Fasciclin domain Cell Adhesion Molecules Developmental Biology |
| Zdroj: | Gene Expression Patterns. 5:593-600 |
| ISSN: | 1567-133X |
| Popis: | All four mammalian fasciclin -containing genes are expressed in the adult valves and are localized in partially overlapping and reciprocal patterns during cardiovascular development. Spatiotemporal comparison of the fasciclin -containing secreted adhesion genes, TGFbeta induced clone H3 ( βigH3 ) and periostin , revealed that they are co-localized within the outflow tract endocardial cushions, but that βigH3 expression is restricted to the septal cushions within the atrioventricular canal. Conversely, the fasciclin -containing transmembrane gene, stabilin-1 , is predominately expressed in the endocardial layer overlaying the cushions and lining the developing heart. However, expression of the fasciclin -containing transmembrane gene, stabilin-2 is only present in the post-natal mature valve endothelial cells. These data illustrate for the first time that the primitive endocardial cushions dynamically express multiple fasciclin -containing adhesion molecules as they undergo the key steps of seeding, proliferation, differentiation, fusion, mesenchymal condensation and remodeling during mouse heart development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect