Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer
| Autor: | David W. Kinne, Linda T. Vahdat, Pamela J. Rosenman, Andrea B. Troxel, Anne Moore, Joel Evans, Elizabeth L. Kaufman, Judith S. Jacobson, Alfred I. Neugut, K. M. Lo, Victor R. Grann, Lorissa Klaus |
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| Rok vydání: | 2001 |
| Předmět: |
Cancer Research
medicine.medical_specialty Antineoplastic Agents Hormonal Black cohosh Breast Neoplasms Placebo law.invention Breast cancer Randomized controlled trial Double-Blind Method Hot flash law Internal medicine medicine Menopausal Symptom Humans Gynecology business.industry Plant Extracts Luteinizing Hormone Middle Aged medicine.disease Combined Modality Therapy Menopause Tamoxifen Oncology Hot Flashes Female medicine.symptom Follicle Stimulating Hormone business medicine.drug |
| Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 19(10) |
| ISSN: | 0732-183X |
| Popis: | PURPOSE: Most breast cancer survivors experience hot flashes; many use complementary or alternative remedies for these symptoms. We undertook a randomized clinical trial of black cohosh, a widely used herbal remedy for menopausal symptoms, among breast cancer patients. PATIENTS AND METHODS: Patients diagnosed with breast cancer who had completed their primary treatment were randomly assigned to black cohosh or placebo, stratified on tamoxifen use. At enrollment, patients completed a questionnaire about demographic factors and menopausal symptoms. Before starting to take the pills and at 30 and 60 days, they completed a 4-day hot flash diary. At the final visit, they completed another menopausal symptom questionnaire. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured in a subset of patients at the first and final visits. RESULTS: Of 85 patients (59 on tamoxifen, 26 not on tamoxifen) enrolled in the study, 42 were assigned to treatment and 43 were assigned to placebo; 69 completed all three hot flash diaries. Both treatment and placebo groups reported declines in number and intensity of hot flashes; the differences between the groups were not statistically significant. Both groups also reported improvements in menopausal symptoms that were, for the most part, not significantly different. Changes in blood levels of FSH and LH also did not differ in the two groups. CONCLUSION: Black cohosh was not significantly more efficacious than placebo against most menopausal symptoms, including number and intensity of hot flashes. Our study illustrates the feasibility and value of standard clinical trial methodology in assessing the efficacy and safety of herbal agents. |
| Databáze: | OpenAIRE |
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