Spectrum of neural electrical activity in guinea pig cochlea: Effects of anaesthesia regimen, body temperature and ambient noise

Autor: D. Clarençon, F. Raffin, I. Sendowski
Přispěvatelé: Centre de Recherches du Service de Santé des Armées (CRSSA), Service de Santé des Armées, This study was supported by the 'Direction des Syste'mes de Force et de la Prospective - De'partement des Techniques des Sciences du Vivant' - DGA (Contract No. 05CO001-05)., Sinniger, Valérie
Rok vydání: 2006
Předmět:
MESH: Tinnitus
Pentobarbital
MESH: Body Temperature
Guinea Pigs
Otoacoustic Emissions
Spontaneous
Ambient noise level
MESH: Anesthesia
MESH: Noise
Body Temperature
MESH: Guinea Pigs
Anaesthesia
Xylazine
Tinnitus
03 medical and health sciences
0302 clinical medicine
MESH: Cochlea
medicine
Animals
Humans
Anesthesia
MESH: Animals
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Cochlear Nerve
Cochlea
030304 developmental biology
0303 health sciences
MESH: Cochlear Nerve
MESH: Electrophysiology
MESH: Humans
Round window
Chemistry
Guinea pig
Sensory Systems
Intensity (physics)
Electrophysiology
Spontaneous activity
medicine.anatomical_structure
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
900 Hz peak
Noise
MESH: Otoacoustic Emissions
Spontaneous
030217 neurology & neurosurgery
Noise (radio)
medicine.drug
Zdroj: Hearing Research
Hearing Research, Elsevier, 2006, 211 (1-2), pp.63-73. ⟨10.1016/j.heares.2005.10.002⟩
ISSN: 0378-5955
DOI: 10.1016/j.heares.2005.10.002
Popis: International audience; Spectral analysis of electric noise recorded from the round window of the cochlea is thought to represent the summed spontaneous activity of the auditory nerve. It has been postulated that it could provide a possible tinnitus index. Because experimental conditions could change this neural activity, the effect of anaesthesia regimen, body temperature and ambient noise on the spectrum of spontaneous neural noise (SNN) were investigated in guinea pig cochlea. SNN was studied in awake guinea pigs and after anaesthesia with pentobarbital (P), xylazine/ketamine (XK) or xylazine/tiletamine-zolazepam (XTZ). Body temperature varied gradually from 33 to 41 degrees C under XK regimen. In awake animals, broadband noise was generated with intensity varying from 0 to 50 dB. The SNN consisted in a broad peak at approximately 900 Hz. With ambient broadband noise, it increased exponentially with the sound level with no shift in frequency. Soon after anaesthetic induction, the lowest frequencies were constantly decreased, and gradually the 900 Hz peak either increased moderately (P) or dropped steeply (XTZ) or remained unchanged (XK). Peak frequency increased linearly with body temperature whereas the amplitude reached a maximum at around 39.5 degrees C. In conclusion, these data indicate that experimental conditions such as anaesthesia regimen, body temperature and ambient noise modify the spontaneous neural outflow of the cochlea and must be taken into account when studying SNN.
Databáze: OpenAIRE
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