Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve
| Autor: | Paola Ferri, Ezio Bombardelli, Bruno C, Paolo Del Grande, Loretta Guidi, Patrizia Ambrogini, Antonella Riva, Cecchini T, Sandra Ciaroni, Paolo Morazzoni, Riccardo Cuppini |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Neurofilament Biology Toxicology Microtubules Pathology and Forensic Medicine Rats Sprague-Dawley Myelin Microtubule medicine Animals Axon Cytoskeleton Myelin Sheath Thiocolchicine Peroneal Nerve Cell Biology General Medicine Anatomy Axons Rats medicine.anatomical_structure nervous system Axoplasm Peripheral nervous system Biophysics Colchicine Injections Intraperitoneal |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0940-2993 |
| DOI: | 10.1078/0940-2993-00249 |
| Popis: | Thiocolchicine is a colchicine-derivative used in the therapy of some diseases and extensively studied in the field of oncological research as antimitotic agent. Here we studied the activity of thiocolchicine on the cytoskeleton of the peroneus nerve, performing a histological and ultrastructural analysis. We observed a decrease in mean myelinated fiber area in thiocolchicine-treated rats in comparison to controls; this was due to a decrease in mean axoplasm area, while myelin thickness was constant. In the ultrastructural analysis a decrease in microtubule density and an increase in neurofilaments were found; moreover, the myelinated fibers seemed to be more affected in comparison to the unmyelinated axons. These findings are in agreement with the capability of binding to microtubule skeleton shared by all the colchicinoids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect