Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma
| Autor: | Federico Garcia-Bragado, Antonio Cardesa, Montserrat Gomà, Jordi Temprana-Salvador, Alfons Nadal, Jaume Ordi, Gabriela Acuña, Llucia Alos |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Larynx Pathology medicine.medical_specialty Time Factors Disease-Free Survival Lymphoepithelial carcinoma Virus Annual incidence Pathology and Forensic Medicine law.invention 03 medical and health sciences 0302 clinical medicine law Biomarkers Tumor Humans Medicine Human papillomavirus Laryngeal Neoplasms P53 expression Cyclin-Dependent Kinase Inhibitor p16 Polymerase chain reaction Aged Medical systems Aged 80 and over Human papillomavirus 16 Hypopharyngeal Neoplasms business.industry Carcinoma Papillomavirus Infections Middle Aged 030104 developmental biology medicine.anatomical_structure Spain 030220 oncology & carcinogenesis DNA Viral Host-Pathogen Interactions Tumor Suppressor Protein p53 business |
| Zdroj: | Modern Pathology. 32:621-626 |
| ISSN: | 0893-3952 2000-2017 |
| DOI: | 10.1038/s41379-018-0188-2 |
| Popis: | The involvement of human papillomavirus (HPV) in laryngeal and hypopharyngeal lymphoepithelial carcinoma was investigated in a series of ten cases (seven laryngeal and three hypopharyngeal), retrieved from the files of three tertiary hospitals in the 2000-2017 period, through polymerase chain reaction with SPF10 primers and INNO-LiPA HPV Genotyping Extra II (Innogenetics). Epstein-Barr virus (EBV) was tested in all cases with in situ hybridization INFORM EBER Probe (Ventana Medical Systems). p16 and p53 expression were immunohistochemically analyzed. Calculated annual incidence was 0.013/100,000, and prevalence was 0.2% of laryngeal and hypopharyngeal carcinomas. All cases were EBV negative. HPV was detected in five cases, three of which also overexpressed p16. HPV16 was detected in four cases, and HPV58 in one case. Five cases were HPV negative, only one of these five overexpressed p16. No recurrence was observed in nine cases during follow-up. The 5-year disease-specific-survival rate was 100%. Mean overall survival was 87 months. Lymphoepithelial carcinoma of the larynx and hypopharynx are not related to EBV. Simultaneous HPV+/p16+ is consistent with HPV causation in a fraction of laryngeal and hypopharyngeal lymphoepithelial carcinomas. |
| Databáze: | OpenAIRE |
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