Prognostic value of 18F-FET PET/CT in newly diagnosed WHO 2016 high-grade glioma
| Autor: | Ronan Abgral, Elsa Magro, Gurvan Dissaux, David Bourhis, Aboubakr Kassoul, Osman El Kabbaj, Benjamin Auberger, Pierre-Yves Salaun, Solène Querellou, Ulrike Schick, Victor Basse |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Brain tumor Contrast Media Observational Study Standardized uptake value Newly diagnosed 03 medical and health sciences 0302 clinical medicine Positron Emission Tomography Computed Tomography Medicine Humans prognostic value 030212 general & internal medicine Prospective Studies Prospective cohort study Survival rate Univariate analysis medicine.diagnostic_test Performance status business.industry glioblastoma Magnetic resonance imaging General Medicine Glioma Middle Aged medicine.disease Prognosis Magnetic Resonance Imaging Survival Rate 030220 oncology & carcinogenesis O-(2-[18F]fluoroethyl)-l-tyrosine positron-emission tomography tumor background ratio Tyrosine Female Neoplasm Grading Radiopharmaceuticals business Nuclear medicine amino acid high-grade glioma Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | O-(2-[18F]fluoroethyl)-l-tyrosine positron-emission tomography/computed tomography (18F-FET PET/CT) is well known in brain tumor management. Our study aimed to identify the prognostic value of 18F-FET PET/CT in high-grade gliomas (HGG) according the current 2016 World Health Organization (WHO) classification. Patients with histologically proven WHO 2016 HGG were prospectively included. A dynamic 18F-FET PET/CT was performed allowing to obtain 2 static PET frames (static frame 1: 20–40 minutes and static frame 2: 2–22 minutes). We analyzed static parameters (standard uptake value [SUV]max, SUVmean, SUVpeak, TBRmax, TBRmean, tumoral lesion glycolysis, and metabolic tumoral volume) for various isocontours (from 10% to 90%). PET parameters, clinical features, and molecular biomarkers were compared with progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analysis. Twenty-nine patients were included (grade III n = 3, grade IV n = 26). Mean PFS and OS were, respectively, 8.8 and 13.9 months. According to univariate analysis, SUVmean, SUVpeak, TBRmax, and TBRmean were significantly correlated with OS. In static 1 analysis, TBRmax seemed to be the best OS prognostic parameter (P = .004). In static 2 analysis, TBRmean was the best parameter (P = .01). In static 1 analysis, only SUVpeak was significant (P = .05) for PFS. Good performance status (PS |
| Databáze: | OpenAIRE |
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