In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives
| Autor: | Rohit Srivastava, Narender Tadigoppula, Arvind K. Srivastava, Jyotsana Pandey, Akhilesh K. Tamrakar, Venkateswarlu Korthikunta, Rohit Singh |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Glucose uptake
medicine.medical_treatment Pharmaceutical Science Chromosomal translocation Biology Anti hyperglycemic Cell Line Drug Discovery medicine Animals Hypoglycemic Agents Isoleucine Muscle Skeletal Pharmacology chemistry.chemical_classification Muscle Cells Glucose Transporter Type 4 Insulin Skeletal muscle In vitro Rats Amino acid Glucose Trigonella medicine.anatomical_structure Complementary and alternative medicine Biochemistry chemistry Seeds Molecular Medicine |
| Zdroj: | Phytomedicine. 22:66-70 |
| ISSN: | 0944-7113 |
| Popis: | The nonproteinogenic amino acid, 4-hydroxyisoleucine (1) has been isolated in large quantities from the fenugreek (T. foenum-graecum) seeds. Few novel derivatives (3–11 and 13–18) were prepared from the naturally occurring 4-hydroxyisoleucine (1) and screened for their in vitro glucose uptake stimulatory effect in L-6 skeletal muscle cells. The derivatives 6, 7, 8, 10 and 11 exhibited better glucose uptake stimulatory activity than parent compound, 4-hydroxyisoleucine at 5 and 10 µM concentrations and compounds 7 and 11 enhanced translocation of insulin sensitive glucose transporters-4 in skeletal muscle cells. |
| Databáze: | OpenAIRE |
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