Food-induced increase in propranolol bioavailability—Relationship to protein and effects on metabolites

Autor:	Edward C. Conradi, U. Kristina Walle, T E Gaffney, Mary-Joan Oexmann, Timothy C. Fagan, Thomas Walle
Rok vydání:	1981
Předmět:	Adult Male Pharmacology Drug Meal Chemistry media_common.quotation_subject Biological Availability Half-life Metabolism Propranolol Urine Bioavailability Protein content Eating medicine Humans Tissue Distribution Pharmacology (medical) Dietary Proteins Half-Life media_common medicine.drug
Zdroj:	Clinical Pharmacology and Therapeutics. 30:790-795
ISSN:	1532-6535 0009-9236
DOI:	10.1038/clpt.1981.239
Popis:	The influence of a meal on the disposition and metabolism of oral propranolol was examined in six normal subjects. The meal induced a mean 53% increase in propranolol bioavailability (range 2% to 92%; P less than 0.01) without affecting time to maximum concentration, half-life, or the amount of unchanges drug in urine. There was no effect on the plasma concentrations of 4-hydroxypropranolol or four other metabolites. The increased bioavailability was linearly related to the protein content of the meal (r = 0.884, P less than 0.02) above a threshold content of about 7 gm.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb5519c0a8eb37099d4dbdaed08796c https://doi.org/10.1038/clpt.1981.239 Zobrazit plný text záznamu Plný text