Biomedical Radioactive Glasses for Brachytherapy
| Autor: | Saeid Kargozar, Luis A. Genova, Sara Ciavattini, Francesco Baino, Juliana Marchi, Elisa Fiume, Roger Borges, Enrica Verne |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Computer science medicine.medical_treatment Brachytherapy bioactive glasses Less invasive Review 02 engineering and technology Bioactive glasses Cancer treatment Durable glasses Microspheres Radioactive Radioisotope lcsh:Technology cancer treatment Microsphere 03 medical and health sciences 0302 clinical medicine medicine General Materials Science Medical physics radioisotope lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 radioactive lcsh:T 021001 nanoscience & nanotechnology durable glasses Radiation therapy Clinical Practice microspheres lcsh:TA1-2040 030220 oncology & carcinogenesis lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology lcsh:TK1-9971 |
| Zdroj: | Materials Materials, Vol 14, Iss 1131, p 1131 (2021) |
| ISSN: | 1996-1944 |
| Popis: | The fight against cancer is an old challenge for mankind. Apart from surgery and chemotherapy, which are the most common treatments, use of radiation represents a promising, less invasive strategy that can be performed both from the outside or inside the body. The latter approach, also known as brachytherapy, relies on the use of implantable beta-emitting seeds or microspheres for killing cancer cells. A set of radioactive glasses have been developed for this purpose but their clinical use is still mainly limited to liver cancer. This review paper provides a picture of the biomedical glasses developed and experimented for brachytherapy so far, focusing the discussion on the production methods and current limitations of the available options to their diffusion in clinical practice. Highly-durable neutron-activatable glasses in the yttria-alumina-silica oxide system are typically preferred in order to avoid the potentially-dangerous release of radioisotopes, while the compositional design of degradable glass systems suitable for use in radiotherapy still remains a challenge and would deserve further investigation in the near future. |
| Databáze: | OpenAIRE |
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