In vitro antiviral activities of ethanol and aqueous extracts of Vietnamese traditional medicinal plants against Porcine Epidemic Diarrhea virus: a coronavirus family member
| Autor: | Thi Bich Ngoc Trinh, Diep Hong Le, Thanh Thi Kim Nguyen, Van Tam Nguyen, Minh Hong Nguyen, Marc Muller, Hai The Pham, Van Phan Le, Thao Kim Nu Nguyen |
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| Rok vydání: | 2021 |
| Předmět: |
Stixis scandens
Traditional medicine Short Communication Porcine epidemic diarrhea virus Biology medicine.disease_cause biology.organism_classification In vitro Coronavirus Vietnamese medicinal plants Diarrhea Minimum inhibitory concentration Infectious Diseases Virology medicine Antiviral activity medicine.symptom Medicinal plants Anisomeles indica Cytopathic effect |
| Zdroj: | VirusDisease |
| ISSN: | 2347-3517 2347-3584 |
| DOI: | 10.1007/s13337-021-00709-z |
| Popis: | Porcine epidemic diarrhea virus (PEDV) causes diarrhea in pigs leading to severe illnesses and high mortality rates. The development of medicinal agents to treat PEDV infection is therefore crucial. In this study, antiviral activities against PEDV of ethanol and aqueous extracts of 17 Vietnamese traditional medicinal plants were evaluated using the cytopathic effect-based assay. The results showed that 14 out of 17 medicinal plants could inhibit the cytopathic effect of PEDV. The ethanol extract of Stixis scandens was identified as the most active extract with its MIC (minimum inhibitory concentration) being 0.15 μg/mL. Other plant extracts also displayed strong antiviral activity against PEDV, including Anisomeles indica, Pericampylus glaucus and Croton kongensis. The results demonstrate that certain medicinal plants have a high antiviral potential and may serve as a lead to develop novel pharmaceutical agents to cure PED as well as the diseases caused by other coronaviruses. |
| Databáze: | OpenAIRE |
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