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Carcinogenesis associated with exposure to radiation is widely known, first reported more than 100 years ago in 1902 by Friben and in 1907 by Porter and White [16]. Exposure to therapeutic doses of radiation have also been shown to be associated with an increased risk of a second cancer, although the precise risk remains unknown. Sarcomas are a rare, but recognized, complication of RT for breast carcinoma, and are associated with poor prognosis. The first description of a bone sarcoma after RT of a breast tumor was reported by Beck in 1922, and Warren and Sommer in 1936 [2] reported a soft tissue sarcoma in the breast treatment volume. The long term incidence of sarcoma after radiation therapy for breast cancer is 0.2 % for 10 years [3]. In 1948, Cahan et al. [2] defined the criteria for the diagnosis of radiation-induced sarcoma. EOO is a soft tissue tumor that produces osteoid, bone or chondroid material without attachment to the skeleton as determined by imaging modalities [4]. Wilson reported the first case of EOO in 1941 and so far only around 300 cases have been reported in the English literature [6]. Most reported cases of osteosarcoma of the chest wall following radiation therapy for breast cancer arise from the chest wall skeletal structures [11]. We describe a rare case of EOO involving the chest wall musculature, after radiation therapy for breast cancer. |
