The origin of domestication genes in goats
| Autor: | Zheng, Z., Wang, X., Li, M., Li, Y., Yang, Z., Pan, X., Gong, M., Zhang, Y., Guo, Y., Wang, Y., Liu, J., Cai, Y., Chen, Q., Okpeku, M., Colli, Licia, Cai, D., Wang, K., Huang, S., Sonstegard, T. S., Esmailizadeh, A., Zhang, W., Tingting, T., Xu, Y., Xu, N., Yang, Y., Han, J., Chen, L., Lesur, J., Daly, K. G., Bradley, D. G., Heller, R., Zhang, G., Wang, W., Chen, Y., Jiang, Y. |
|---|---|
| Přispěvatelé: | Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Introgression
Locus (genetics) Biology Genome domestication 03 medical and health sciences 0302 clinical medicine whole-genome data Genetics Allele Domestication ancient DNA Gene Research Articles ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Multidisciplinary Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO goat Haplotype SciAdv r-articles biochemical phenomena metabolism and nutrition Evolutionary biology [SDE]Environmental Sciences 030217 neurology & neurosurgery Research Article Human mitochondrial DNA haplogroup |
| Zdroj: | Science Advances Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (21), pp.eaaz5216. ⟨10.1126/sciadv.aaz5216⟩ Zheng, Z, Wang, X, Li, M, Li, Y, Yang, Z, Wang, X, Pan, X, Gong, M, Zhang, Y, Guo, Y, Wang, Y, Liu, J, Cai, Y, Chen, Q, Okpeku, M, Colli, L, Cai, D, Wang, K, Huang, S, Sonstegard, T S, Esmailizadeh, A, Zhang, W, Zhang, T, Xu, Y, Xu, N, Yang, Y, Han, J, Chen, L, Lesur, J, Daly, K G, Bradley, D G, Heller, R, Zhang, G, Wang, W, Chen, Y & Jiang, Y 2020, ' The origin of domestication genes in goats ', Science Advances, vol. 6, no. 21, eaaz5216 . https://doi.org/10.1126/sciadv.aaz5216 |
| ISSN: | 2375-2548 |
| Popis: | Goat domestication selection mainly focused on immune and neural genes and involved both standing and introgressed variation. Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically cryptic evolutionary transformations provides new insights into the mechanisms of animal domestication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|