Characterization of enzootic nasal tumour virus of goats: complete sequence and tissue distribution
| Autor: | Zoraida Pascual, E. Minguijón, J. Michael Sharp, Christina Cousens, Maider Pérez de Villarreal, Marcelo de las Heras, A. Ortín |
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| Rok vydání: | 2003 |
| Předmět: |
Whole genome sequencing
Goat Diseases Base Sequence biology Lymphoid Tissue Sequence analysis Goats viruses Molecular Sequence Data Nose Neoplasms Sequence Analysis DNA biology.organism_classification Jaagsiekte sheep retrovirus Virology Genome Virus Tumor Virus Infections Complete sequence Retroviridae Retrovirus Animals Enzootic Retroviridae Infections |
| Zdroj: | Journal of General Virology. 84:2245-2252 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/vir.0.19125-0 |
| Popis: | The complete genome sequence of a new isolate of enzootic nasal tumour virus (ENTV-2), associated with enzootic nasal adenocarcinoma (ENA) of goats, was determined. The genome exhibits a genetic organization characteristic of beta-retroviruses. ENTV-2 is closely related to the retrovirus (ENTV-1) associated with enzootic adenocarcinoma of sheep, and to jaagsiekte retrovirus. The main sequence differences between these viruses reside in orfX, the U3 LTR, two small regions in gag and the transmembrane (TM) region of env. Sequence analysis of the TM region of env from several sheep and goats naturally affected by ENA suggested that ENTV-1 and ENTV-2 are distinct viruses rather than geographical variants. Although both viruses transform secretory epithelial cells of the ethmoid turbinate, the study of their tissue distribution using specific PCRs showed that ENTV-2 establishes a disseminated lymphoid infection whereas ENTV-1 is mainly confined to the tumour. |
| Databáze: | OpenAIRE |
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