(-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes
| Autor: | J P Condreay, M T Paff, Devron Averett, Lynn D. Condreay, Robert Jansen |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Hepatitis B virus
Time Factors Virus Replication medicine.disease_cause Antiviral Agents Virus chemistry.chemical_compound medicine Emtricitabine Humans Pharmacology (medical) Hydroxymethyl Cells Cultured Pharmacology biology Zalcitabine biology.organism_classification Virology Blotting Southern Infectious Diseases medicine.anatomical_structure Liver chemistry Hepadnaviridae Viral replication Cell culture Hepatocyte Cytosine Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 40:520-523 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.40.2.520 |
| Popis: | The anti-hepatitis B virus (HBV) activity of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) in cultures of primary human hepatocytes was examined. 524W91 was anabolized to the active 5'-triphosphate in these cells. HBV replication was equally inhibited in cultures incubated with 524W91 when the drug was added 24 h preinfection, at infection, or 24 h postinfection. 524W91 inhibited HBV replication by 50% at less than 20 nM in human hepatocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|