Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease
Autor: | Jaqueline C Geraldis, Estela M. Bruxel, Danielle do Carmo Ferreira Bruno, Alexandre B Godoi, Mariana Martin, Amanda Morato do Canto, Iscia Lopes-Cendes |
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Rok vydání: | 2021 |
Předmět: |
Adult
Adult population Disease Severe epilepsy Hippocampus Lesion 03 medical and health sciences Epilepsy 0302 clinical medicine medicine Humans Hippocampal sclerosis Sclerosis business.industry General Medicine medicine.disease Magnetic Resonance Imaging nervous system diseases Epilepsy Temporal Lobe Neurology Multi omics Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery Mesial temporal lobe epilepsy |
Zdroj: | Seizure. 90:34-50 |
ISSN: | 1059-1311 |
Popis: | Mesial temporal lobe epilepsy (MTLE) is one of the most common types of focal epilepsy in the adult population. MTLE is frequently associated with a specific histopathological lesion in the medial temporal structures, namely hippocampal sclerosis (HS). A significant proportion of patients with MTLE+HS have severe epilepsy, which is often resistant to clinical treatment. For these patients, surgical resection of the epileptogenic lesion can be performed. Our understanding of the underlying mechanisms leading to MTLE+HS has improved significantly over the past few decades. In this review, we aim to present and discuss the most recent findings regarding the genetic determinants of MTLE+HS. Furthermore, we will address studies about transcriptomics, proteomics, metabolomics, and epigenomic signatures of the tissue that is surgically removed from patients with refractory MTLE+HS and animal models of the disorder. We expect to provide an overview and a critical discussion of the findings, limitations, new approaches, and future directions for multi-omics studies in MTLE+HS. |
Databáze: | OpenAIRE |
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