Regional distribution and behavioral correlates of 5-HT2A receptors in Alzheimer's disease with [18F]deuteroaltanserin and PET
| Autor: | Gilles Tamagnan, Ronald M. Baldwin, Lekshmi Santhosh, Kristina M. Estok, Christopher H. van Dyck, Effie M. Mitsis, Martha G. MacAvoy, Rebecca S. Vogel, Julie K. Staley |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Cingulate cortex Fluorine Radioisotopes Postmortem studies medicine.medical_specialty Pathology Neuroscience (miscellaneous) Serotonergic Brain mapping Central nervous system disease Degenerative disease Alzheimer Disease Internal medicine Brief Psychiatric Rating Scale medicine Humans Receptor Serotonin 5-HT2A Radiology Nuclear Medicine and imaging Aged Aged 80 and over Analysis of Variance Brain Mapping Brain Middle Aged medicine.disease Psychiatry and Mental health Endocrinology Positron-Emission Tomography Female Ketanserin Alzheimer's disease Psychology Protein Binding |
| Zdroj: | Psychiatry Research: Neuroimaging. 173:212-217 |
| ISSN: | 0925-4927 |
| Popis: | Postmortem studies show reductions in brain serotonin 2A (5-HT(2A)) receptors in Alzheimer's disease (AD). Converging evidence also suggests that serotonergic dysregulation may contribute to behavioral symptoms that frequently occur in AD. This study aimed to define regional reductions in 5-HT(2A) binding in AD patients and to examine their behavioral correlates. Nine patients with probable AD and eight elderly controls were studied using a constant infusion paradigm for equilibrium modeling of [(18)F]deuteroaltanserin with positron emission tomography (PET). Region of interest analyses were performed on PET images coregistered to MRI scans. The outcome measures BP(P) (ratio of specific brain uptake to total plasma parent concentration) and BP(ND) (ratio of specific to nondisplaceable uptake) were obtained for pertinent cortical and subcortical regions. AD patients showed a statistically significant decrease in the anterior cingulate in both BP(P) and BP(ND), but in no other region. Within the AD patient sample, no significant correlations were observed between regional 5-HT(2A) binding and behavioral measures, including depressive and psychotic symptoms. These results confirm a reduction in cortical 5-HT(2A) receptors in AD, specifically in the anterior cingulate. However, in a limited AD patient sample, they fail to demonstrate a relationship between regional 5-HT(2A) binding and major behavioral symptoms. |
| Databáze: | OpenAIRE |
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