Passive smoking and platelet thromboxane
| Autor: | Yannis Stamatopoulos, Peter Schmid, Georg Karanikas, Bernhard A. Peskar, Christian Pirich, H. Kritz, Helmut Sinzinger |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Passive smoking Platelet Function Tests Thromboxane medicine.disease_cause Thromboxane Production Thromboxane A2 chemistry.chemical_compound Malondialdehyde Internal medicine medicine Humans Platelet Chemistry Hematology Thromboxane B2 Endocrinology Hemostasis Anesthesia Female Tobacco Smoke Pollution |
| Zdroj: | Thrombosis Research. 81:451-460 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(96)00017-5 |
| Popis: | While active smoking is known to enhance platelet thromboxane production, no data on passive smoking is available yet. The influence of single and repeated exposure to passive smoke for 60 minutes in a 18 m3 room was assessed in non-smokers as compared to sex and age matched smokers. All the evaluated measures (malondialdehyde, plasma thromboxane B2, 11-dehydro-thromboxane B2, serum thromboxane B2, conversion of exogenous arachidonic acid to thromboxane B2 and to hydroxy-5, 8,10-heptadecatrienoic acid) were higher in smokers than non-smokers at baseline, immediately and 6 hours after passive exposure to cigarette smoke. Repeated exposure of non-smokers rendered their platelets more activated becoming close to the behaviour of smokers. These results indicate that passive smoking may activate thromboxane A2 release from the platelets, contributing to the development of hemostatic imbalance. |
| Databáze: | OpenAIRE |
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