Favorable revascularization therapy in patients with ASPECTS ≤ 5 on DWI in anterior circulation stroke
| Autor: | Carlos Riquelme, Alain Bonafe, M. Moynier, Cyril Dargazanli, Vincent Costalat, Xavier Ayrignac, Caroline Arquizan, Gregory Gascou, Tzvika Sacagiu, Eitan Abergel, Omer Eker, Daniel Mantilla, Isabelle Mourand |
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| Přispěvatelé: | Département de Neuroradiologie[Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université de Montpellier (UM), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty [SDV]Life Sciences [q-bio] medicine.medical_treatment Cerebral Revascularization Revascularization Alberta 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Reperfusion therapy Modified Rankin Scale medicine Humans Thrombolytic Therapy Stroke Aged Retrospective Studies Thrombectomy Aged 80 and over Cerebral infarction business.industry Retrospective cohort study General Medicine Thrombolysis Middle Aged medicine.disease 3. Good health Surgery Diffusion Magnetic Resonance Imaging Treatment Outcome Cerebrovascular Circulation Female Neurology (clinical) Tomography X-Ray Computed business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurointerventional Surgery Journal of Neurointerventional Surgery, BMJ Journals, 2018, 10 (1), pp.5--9. ⟨10.1136/neurintsurg-2017-013358⟩ |
| ISSN: | 1759-8486 1759-8478 |
| DOI: | 10.1136/neurintsurg-2017-013358 |
| Popis: | BackgroundA low baseline Alberta Stroke Programme Early CT Score (ASPECTS) is strongly associated with low rates of favorable outcome in patients with acute stroke.ObjectiveTo evaluate the efficacy and safety of revascularization therapy in patient with ASPECTS ≤5 in anterior circulation infarct.MethodsWe retrospectively analyzed 108 consecutive patients presenting low ASPECTS on diffusion-weighted imaging. Sixty patients were treated by mechanical thrombectomy, including 34 patients who received simultaneously intravenous thrombolysis. A control group of 48 patients not eligible for reperfusion therapy gave us a perspective on the natural history. Clinical outcome was evaluated at 90 days using the modified Rankin Scale (mRS) score. Hemicraniectomy after malignant infarction, mortality, and symptomatic intracranial haemorrhage (sICH) were also reported.ResultsThrombolysis in Cerebral Infarction 2b–3 was assessed in 75% of treated patients. Reperfusion therapy led to significantly reduced disability (mRS score 0–2) at 90 days compared with the control group (30% vs 2.1%, pConclusionsIn patients with acute stroke in the anterior circulation and ASPECTS ≤5 revascularization therapy contributes to a favorable clinical outcome at 90 days, especially in patients younger than 70 years. |
| Databáze: | OpenAIRE |
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