Metabolic abnormalities in patients with primary open-angle glaucoma
| Autor: | Rigas Kalaitzidis, Moses Elisaf, Kostas Psilas, George Kitsos, Eleni Bairaktari, Christos Kalogeropoulos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty genetic structures Open angle glaucoma Glaucoma Disease Carbohydrate metabolism Uric Acid/blood Pathogenesis Diabetes Complications chemistry.chemical_compound Metabolic Diseases Risk Factors Diabetes mellitus Internal medicine medicine Humans Hyperuricemia Aged business.industry Metabolic Diseases/blood/*complications Blood Glucose/analysis Middle Aged medicine.disease eye diseases Glaucoma Open-Angle/blood/*complications/etiology Uric Acid Ophthalmology Endocrinology chemistry Uric acid Carbohydrate Metabolism Female business Glaucoma Open-Angle |
| Popis: | Purpose: Although there are few data on the underlying mechanisms of primary open-angle glaucoma (POAG), it has been suggested that metabolic diseases may play a role in the evolution of the disease. We carried out the present study to investigate the involvement of metabolic disturbances in POAG pathogenesis. Material/methods: Serum metabolic parameters were evaluated in 49 POAG patients without a known history of diabetes mellitus and 72 age and sex matched individuals without glaucoma (control group). Results: Among the metabolic parameters examined, only fasting serum glucose and uric acid levels were found significantly higher in patients with glaucoma compared to the control population (117±17 mg/dl vs 105±11 mg/dl, p=0.05 and 6.2±1.9 mg/dl vs 5±1.2 mg/dl, p=0.006, respectively). Additionally, a considerably greater proportion of patients had disturbances of the carbohydrate metabolism and hyperuricemia. Conclusion: We conclude that disturbances of carbohydrate and uric acid metabolism could play a role in glaucoma damage and pathogenesis. |
| Databáze: | OpenAIRE |
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