Pediatric nonalcoholic fatty liver disease – a changing diagnostic paradigm
| Autor: | Stefan Chiriac, Alin Constantin Iordache, Laura Mihaela Trandafir, Otilia Elena Frasinariu, Maria Magdalena Leon-Constantin, Ingrith Miron, Elena Cojocaru, Mioara Florentina Trandafirescu, Alina Costina Luca |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Liver Cirrhosis Embryology Pediatrics medicine.medical_specialty non-invasive biomarkers Adolescent scoring systems steatohepatitis Review Disease Overweight Chronic liver disease Pathology and Forensic Medicine Pathogenesis Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease medicine Humans Obesity Child Ultrasonography medicine.diagnostic_test business.industry hepatic steatosis Public health fibrosis nutritional and metabolic diseases Cell Biology General Medicine medicine.disease digestive system diseases Liver biopsy fatty liver disease medicine.symptom business Developmental Biology |
| Zdroj: | Romanian Journal of Morphology and Embryology |
| ISSN: | 2066-8279 1220-0522 |
| Popis: | Worldwide, nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease in children and adolescents, but also as a real public health issue. Over the last decades, the increase in the rates of obesity and overweight in children has led to the increase in the worldwide prevalence of pediatric NAFLD. Detection of a hyperechoic appearance of the liver at ultrasounds or elevated levels of transaminases, identified during a routine control in children, suggests NAFLD. The disorder can be diagnosed with either non-invasive strategies or through liver biopsy, which further allows the identification of specific histological aspects, distinct from those found in adults. Since NAFLD is a clinically heterogeneous disease, there is an imperative need to identify noninvasive biomarkers and screening techniques for early diagnosis in children, in order to prevent metabolic and cardiovascular complications later in adulthood. This review emphasizes the main diagnosis tools in pediatric NAFLD, a systemic disorder with multifactorial pathogenesis and varying clinical manifestations. |
| Databáze: | OpenAIRE |
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