Diagnosis of Liver Fibrosis With Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFA-M2BP) Among Chronic Hepatitis B Patients

Autor: Pil Soo Sung, Sung Won Lee, Seung Kew Yoon, Hyunyu Choi, Hein Yu, Dong Wook Jekarl, Seungok Lee, Yonggoo Kim, Jung Hyun Kwon, Myungshin Kim
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Liver Cirrhosis
Male
Receptors
N-Acetylglucosamine
Clinical Biochemistry
medicine.disease_cause
Gastroenterology
0302 clinical medicine
Fibrosis
Diagnosis
Immunoassay
Membrane Glycoproteins
medicine.diagnostic_test
biology
General Medicine
Middle Aged
Wisteria floribunda
Hepatitis B
Liver
030220 oncology & carcinogenesis
Liver biopsy
Area Under Curve
Biomarker (medicine)
Liver Fibrosis
Elasticity Imaging Techniques
030211 gastroenterology & hepatology
Original Article
Female
Plant Lectins
Wisteria floribunda agglutinin-positive Mac-2 binding protein
Adult
Blood Platelets
medicine.medical_specialty
Efficacy
Hepatitis C virus
Aspartate transaminase
Context (language use)
03 medical and health sciences
Hepatitis B
Chronic
Antigens
Neoplasm
Internal medicine
medicine
Humans
Aspartate Aminotransferases
Diagnostic Immunology
Retrospective Studies
Hepatitis B virus
business.industry
Platelet Count
Biochemistry (medical)
medicine.disease
biology.organism_classification
ROC Curve
Multivariate Analysis
biology.protein
business
Biomarkers
Zdroj: Annals of Laboratory Medicine
ISSN: 2234-3814
2234-3806
Popis: BACKGROUND Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP) is a protein with altered glycosylation that reacts with lectin, and was recently identified as a useful non-invasive biomarker for the diagnosis of liver fibrosis in patients with hepatitis C virus infection.This study aimed to evaluate the diagnostic efficacy of WFA-M2BP for liver fibrosis in the context of hepatitis B virus (HBV). METHODS We enrolled 151 patients infected with HBV. Liver biopsy and elastography (Fibroscan) were performed during the initial visit. Fibrosis was graded according to the Knodell histologic activity index (F0-3). WFA-M2BP levels were determined with an automated immunoassay analyzer (M2BPGi, HISCL-5000, Sysmex, Japan). The diagnostic efficacy of WFA-M2BP was compared with those of various conventional or composite biomarkers, including enhanced liver fibrosis (ELF) score, Fibroscan, aspartate transaminase (AST)-to-platelet ratio index (APRI), and FIB-4, based on the area under the ROC curve (AUC) value. RESULTS The majority of patients were at fibrosis stages F1 and F2. The F2 and F3 AUC values for WFA-M2BP were similar to those for FIB-4, APRI, ELF, and Fibroscan, although the latter showed the best diagnostic efficacy. The diagnostic accuracy of all tested biomarkers for F2 and F3 was 60-70%. In multivariate analysis, WFA-M2BP, ELF, and platelet count significantly predicted stage ≥F2, whereas only platelet count significantly predicted F3. CONCLUSIONS WFA-M2BP can support a diagnosis of liver fibrosis with similar diagnostic efficacy to other biomarkers, and predicted liver fibrosis stage ≥2 among patients with chronic hepatitis B.
Databáze: OpenAIRE
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