Diagnosis of Liver Fibrosis With Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFA-M2BP) Among Chronic Hepatitis B Patients
Autor: | Pil Soo Sung, Sung Won Lee, Seung Kew Yoon, Hyunyu Choi, Hein Yu, Dong Wook Jekarl, Seungok Lee, Yonggoo Kim, Jung Hyun Kwon, Myungshin Kim |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Liver Cirrhosis
Male Receptors N-Acetylglucosamine Clinical Biochemistry medicine.disease_cause Gastroenterology 0302 clinical medicine Fibrosis Diagnosis Immunoassay Membrane Glycoproteins medicine.diagnostic_test biology General Medicine Middle Aged Wisteria floribunda Hepatitis B Liver 030220 oncology & carcinogenesis Liver biopsy Area Under Curve Biomarker (medicine) Liver Fibrosis Elasticity Imaging Techniques 030211 gastroenterology & hepatology Original Article Female Plant Lectins Wisteria floribunda agglutinin-positive Mac-2 binding protein Adult Blood Platelets medicine.medical_specialty Efficacy Hepatitis C virus Aspartate transaminase Context (language use) 03 medical and health sciences Hepatitis B Chronic Antigens Neoplasm Internal medicine medicine Humans Aspartate Aminotransferases Diagnostic Immunology Retrospective Studies Hepatitis B virus business.industry Platelet Count Biochemistry (medical) medicine.disease biology.organism_classification ROC Curve Multivariate Analysis biology.protein business Biomarkers |
Zdroj: | Annals of Laboratory Medicine |
ISSN: | 2234-3814 2234-3806 |
Popis: | BACKGROUND Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP) is a protein with altered glycosylation that reacts with lectin, and was recently identified as a useful non-invasive biomarker for the diagnosis of liver fibrosis in patients with hepatitis C virus infection.This study aimed to evaluate the diagnostic efficacy of WFA-M2BP for liver fibrosis in the context of hepatitis B virus (HBV). METHODS We enrolled 151 patients infected with HBV. Liver biopsy and elastography (Fibroscan) were performed during the initial visit. Fibrosis was graded according to the Knodell histologic activity index (F0-3). WFA-M2BP levels were determined with an automated immunoassay analyzer (M2BPGi, HISCL-5000, Sysmex, Japan). The diagnostic efficacy of WFA-M2BP was compared with those of various conventional or composite biomarkers, including enhanced liver fibrosis (ELF) score, Fibroscan, aspartate transaminase (AST)-to-platelet ratio index (APRI), and FIB-4, based on the area under the ROC curve (AUC) value. RESULTS The majority of patients were at fibrosis stages F1 and F2. The F2 and F3 AUC values for WFA-M2BP were similar to those for FIB-4, APRI, ELF, and Fibroscan, although the latter showed the best diagnostic efficacy. The diagnostic accuracy of all tested biomarkers for F2 and F3 was 60-70%. In multivariate analysis, WFA-M2BP, ELF, and platelet count significantly predicted stage ≥F2, whereas only platelet count significantly predicted F3. CONCLUSIONS WFA-M2BP can support a diagnosis of liver fibrosis with similar diagnostic efficacy to other biomarkers, and predicted liver fibrosis stage ≥2 among patients with chronic hepatitis B. |
Databáze: | OpenAIRE |
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