Influence of antimuscarinic substances on in vitro synthesis of acetylcholine by rat cerebral cortex
| Autor: | R. L. Polak, Maria M. Bertels-Meeuws |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1968 |
| Předmět: |
Atropine
Physostigmine Scopolamine Pharmacology In Vitro Techniques chemistry.chemical_compound Cocaine Cortex (anatomy) medicine Choline Animals Cholinesterase Cerebral Cortex Plants Medicinal biology General Medicine Acetylcholine Rats Lysergic Acid Diethylamide Plants Toxic medicine.anatomical_structure chemistry Cerebral cortex Atropa belladonna Phenobarbital biology.protein Potassium Female Cholinesterase Inhibitors medicine.drug Research Article |
| Popis: | When a solution of a cholinesterase inhibitor is brought into contact with the exposed cerebral cortex or the ventricular surface of the caudate nucIeus of a living animal, acetyl- choline (ACh) is liberated into this fluid. There is an increase in the amount of ACh released when atropine is added to the solution or injected intravenously (Mitchell, 1963 ; Szerb, 1964; Polak, 1965). ',: In the following experiments the influence of atropine and some atropine-like drugs was studied on the release and synthesis of ACh by slices of cortex from rat brain, treated with a cholinesterase (ChE) inhibitor. In certain conditions atropine was found to en- hance the release of ACh from the tissue into the incubation medium and this increased release was associated with an increased synthesis of ACh. Some other antimuscarinic compounds also stimulated ACh output. I Preliminary reports of some of the results of this investigation have been published elsewhere (Polak and Meeuws, 1966; Polak, 1967). |
| Databáze: | OpenAIRE |
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