Cryogen‐free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T

Autor: Oleksandr Rybalko, Jan Henrik Ardenkjær-Larsen, Sean Bowen, Marcus Görge Ullisch, Niels Chr. Nielsen, Jan Raagaard Petersen, Mads Sloth Vinding
Rok vydání: 2018
Předmět:
Physics - Instrumentation and Detectors
Hot Temperature
Magnetic Resonance Spectroscopy
Time Factors
Materials science
dissolution dynamic nuclear polarization
FOS: Physical sciences
Helium
Pattern Recognition
Automated
030218 nuclear medicine & medical imaging
law.invention
Magnetics
03 medical and health sciences
0302 clinical medicine
law
polarizer
Pyruvic Acid
Water cooling
Radiology
Nuclear Medicine and imaging
Hyperpolarization (physics)
Carbon-13 Magnetic Resonance Spectroscopy
Dissolution
hyperpolarization
business.industry
Temperature
Time constant
dry magnet
Instrumentation and Detectors (physics.ins-det)
Equipment Design
RESONANCE
Polarizer
Polarization (waves)
Physics - Medical Physics
Magnetic field
Magnetic Fields
Magnet
Optoelectronics
Medical Physics (physics.med-ph)
business
Algorithms
Software
030217 neurology & neurosurgery
Zdroj: Ardenkjær-Larsen, J H, Bowen, S, Petersen, J R, Rybalko, O, Vinding, M S, Ullisch, M & Nielsen, N C 2019, ' Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T ', Magnetic Resonance in Medicine, vol. 81, no. 3, pp. 2184-2194 . https://doi.org/10.1002/mrm.27537
ISSN: 1522-2594
0740-3194
DOI: 10.1002/mrm.27537
Popis: Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, pre-clinical and clinical applications. Method: It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. Results: It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13C]pyruvate of 70%. The build-up time constant in the solid state is approx. 1200 s (20 min), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. Conclusion: We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, automation and fluid handling systems; we have designed a unique dDNP system with unrivalled flexibility and performance.
Comment: 16 pages, 8 figures
Databáze: OpenAIRE
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