Intracranial hypertension associated with obstructive sleep apnea: A discussion of potential etiologic factors
| Autor: | D.E. Wardly |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Intracranial Pressure medicine.medical_treatment Models Neurological Glutamic Acid Blood–brain barrier medicine Edema Humans Obesity Continuous positive airway pressure Blood Coagulation Intracranial pressure Sleep Apnea Obstructive Continuous Positive Airway Pressure Brain edema business.industry Hematologic Factors Sleep apnea General Medicine medicine.disease Obstructive sleep apnea medicine.anatomical_structure Blood-Brain Barrier Anesthesia Female Intracranial Hypertension Glutamic acid metabolism business |
| Zdroj: | Medical Hypotheses. 83:792-797 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2014.10.011 |
| Popis: | Obstructive sleep apnea has been shown to increase intracranial pressure, and to be a secondary cause of intracranial hypertension. There are a few theories that attempt to explain this relationship, however there is little data, and even less recognition among physicians that this actually occurs. This paper discusses multiple pieces of data, from anatomical correlates to biochemical information involving neuro-excitotoxicity, as well as hematologic factors and issues surrounding brain edema and blood-brain barrier dysfunction. A complex paradigm for how obstructive sleep apnea may lead to increased intracranial pressure is thus proposed. In addition, suggestions are made for how obstructive sleep apnea must as a result be managed differently in the setting of idiopathic intracranial hypertension. |
| Databáze: | OpenAIRE |
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