Takayasu’s arteritis mimicking Kawasaki disease in 7-month-old infant, successfully treated with glucocorticosteroids and intravenous immunoglobulins
| Autor: | Beata Kierzkowska, Katarzyna Niewiadomska-Jarosik, Jerzy Stańczyk, Elżbieta Smolewska, Dobromiła Barańska, Małgorzata Biernacka-Zielińska, Joanna Lipińska |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pediatrics Immunology Takayasu's arteritis Mucocutaneous Lymph Node Syndrome Irritability Diagnosis Differential Rheumatology medicine.artery Internal medicine medicine Humans Immunology and Allergy Arteritis Glucocorticoids business.industry Standard treatment Abdominal aorta Immunoglobulins Intravenous Infant medicine.disease Takayasu Arteritis Surgery Discontinuation Treatment Outcome Female Kawasaki disease medicine.symptom business |
| Zdroj: | Rheumatology International. 32:3655-3659 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-010-1518-y |
| Popis: | Takayasu's arteritis (TA) rarely occurs in infants. There are only four reports on TA in children below 1 year of age, revealing diversity of its symptoms. We describe a 7-month-old female infant hospitalized for hectic fever, irritability, high acute phase indices, and coronary artery dilatations found on echocardiography, which suggested Kawasaki disease (KD). Despite of standard treatment, rapid development of thoracic and abdominal aorta aneurysms occurred, while coronary artery abnormalities regressed. The initial diagnosis was changed for TA. Subsequently implemented glucocorticosteroids led to clinical and laboratory normalization. However, 2 months after treatment discontinuation, TA relapsed. Glucocorticosteroid therapy was restarted with additional introduction of intravenous immunoglobulins (IVIG), resulting in full and stable remission lasting over 1 year. Thus, diagnosis and treatment of infant TA pose a big challenge to physicians. TA onset in infants may mimics KD. Prolonged glucocorticosteroids and IVIG administration can be recommended in the youngest patients with TA. |
| Databáze: | OpenAIRE |
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