Skilled movements require non-apoptotic Bax/Bak pathway-mediated corticospinal circuit reorganization
| Autor: | Mishi Liang, Zirong Gu, John H. Martin, Yutaka Yoshida, Najet Serradj, Masaki Ueno, Mark L. Baccei, Jie Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Motor circuit Patch-Clamp Techniques Blotting Western Walking Biology Article 03 medical and health sciences Mice 0302 clinical medicine medicine Biological neural network Animals Muscle Skeletal bcl-2-Associated X Protein Neurons Microscopy Confocal Hand Strength Electromyography General Neuroscience Motor Cortex Muscle activation Spinal cord Immunohistochemistry Axons Electric Stimulation Electrophysiology 030104 developmental biology medicine.anatomical_structure bcl-2 Homologous Antagonist-Killer Protein Spinal Cord Apoptosis Motor Skills Caspases Neuroscience 030217 neurology & neurosurgery Motor cortex Signal Transduction |
| Popis: | Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganization occurs during postnatal development remains poorly understood. Here we explore the connectivity between corticospinal (CS) neurons in the motor cortex and muscles in mice. Using trans-synaptic viral and electrophysiological assays, we identify the early postnatal reorganization of CS circuitry for antagonistic muscle pairs. We further show that this synaptic rearrangement requires the activity-dependent, non-apoptotic Bax/Bak-caspase signaling cascade. Adult Bax/Bak mutant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval behaviors. Our findings reveal key cellular and molecular mechanisms driving postnatal motor circuit reorganization and the resulting impacts on muscle activation patterns and the execution of skilled movements. |
| Databáze: | OpenAIRE |
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