Treatment outcome and risk analysis for cataract after radiotherapy of localized ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma
| Autor: | Hee Hyun Park, Sea Won Lee, Byung Oak Choi, Soo Yoon Sung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Marginal zone B-cell lymphoma medicine.medical_treatment Cataract 03 medical and health sciences 0302 clinical medicine Cataracts Internal medicine medicine Radiology Nuclear Medicine and imaging Clinical Investigation Stage (cooking) Radiotherapy Proportional hazards model business.industry Hazard ratio MALT lymphoma medicine.disease eye diseases Radiation therapy 030220 oncology & carcinogenesis 030221 ophthalmology & optometry Original Article Radiology business Mucosa-associated lymphoid tissue |
| Zdroj: | Radiation Oncology Journal |
| ISSN: | 2234-3164 2234-1900 |
| Popis: | Purpose We retrospectively reviewed the results of radiotherapy for localized ocular adnexal MALT lymphoma (OAML) to investigate the risk factors of cataract. Methods Sixty-seven patients with stage IE OAML treated with radiotherapy at Seoul St. Mary's Hospital from 2001 to 2016 were included. Median treatment dose was 30 Gy. Lens protection was done in 52 (76%) patients. Radiation therapy (RT) extent was as follows: superficial (82.1%), tumor mass (4.5%), and entire orbital socket (13.4%). The risk factors for symptomatic cataract were analyzed using the Cox proportional hazard model. Results Median follow-up time was 50.9 months (range, 1.9 to 149.4 months). All patients were alive at the time of analysis. There were 7 recurrences and there was no local recurrence. Median time to recurrence was 40.4 months. There were 14 cases of symptomatic cataract. Dose >30 Gy had hazard ratio of 3.47 for cataract (p = 0.026). Omitting lens protection showed hazard ratio of 4.10 (p = 0.008). Conclusions RT achieves excellent local control of ocular MALT lymphoma. Consideration of RT-related factors such as lens protection and radiation dose at the stage of RT planning may reduce the risk of RT-induced cataract after radiotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|