Interrater and intrarater agreement of confocal microscopy imaging in diagnosing and subtyping basal cell carcinoma

Autor: D.J. Kadouch, A.S.E. van Haersma de With, Y.S. Elshot, M. Peppelman, M.W. Bekkenk, A. Wolkerstorfer, I. Eekhout, C.A.C. Prinsen, M.A. de Rie
Přispěvatelé: Dermatology, CCA - Imaging and biomarkers, Other departments, Plastic, Reconstructive and Hand Surgery, Epidemiology and Data Science, APH - Methodology
Rok vydání: 2018
Předmět:
Adult
Male
Reflectance confocal microscopy
Skin Neoplasms
Original Articles and Short Reports Oncology
Dermatology
law.invention
Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2]
030207 dermatology & venereal diseases
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Confocal microscopy
law
Humans
Medicine
Basal cell carcinoma
Prospective Studies
030212 general & internal medicine
skin and connective tissue diseases
Reference standards
Aged
Aged
80 and over
Observer Variation
Microscopy
Confocal
integumentary system
business.industry
Carcinoma
fungi
Reproducibility of Results
Middle Aged
medicine.disease
Subtyping
Infectious Diseases
Carcinoma
Basal Cell
Original Article
Female
Surgical excision
Observer variation
business
Nuclear medicine
Zdroj: Journal of the European Academy of Dermatology and Venereology, 32(8), 1278-1283. Wiley-Blackwell
Kadouch, D J, van Haersma de With, A, Elshot, Y S, Peppelman, M, Bekkenk, M W, Wolkerstorfer, A, Eekhout, I, Prinsen, C A C & de Rie, M A 2018, ' Inter-rater and intra-rater agreement of confocal microscopy imaging in diagnosing and subtyping basal cell carcinoma ', JEADV. Journal of the European Academy of Dermatology and Venereology, vol. 32, no. 8, pp. 1278-1283 . https://doi.org/10.1111/jdv.14771
JEADV. Journal of the European Academy of Dermatology and Venereology, 32(8), 1278-1283. Wiley-Blackwell
Journal of the European Academy of Dermatology and Venereology, 8, 32, 1278-1283
Journal of the European Academy of Dermatology and Venereology
JEADV : Journal of the European Academy of Dermatology and Venereology, 32, 8, pp. 1278-1283
JEADV : Journal of the European Academy of Dermatology and Venereology, 32, 1278-1283
ISSN: 0926-9959
Popis: BACKGROUND: Reflectance confocal microscopy (RCM) imaging can be used to diagnose and subtype basal cell carcinoma (BCC) but relies on individual morphologic pattern recognition that might vary among users.OBJECTIVES: We assessed the inter-rater and intra-rater agreement of RCM in correctly diagnosing and subtyping BCC.METHODS: In this prospective study we evaluated the inter-rater and intra-rater agreement of RCM on BCC presence and subtype among three raters with varying experience who independently assessed static images of 48 RCM cases twice with four weeks interval (T1 and T2). Histopathologic confirmation of presence and subtype of BCC from surgical excision specimen was defined as the reference standard.RESULTS: The inter-rater agreement of RCM for BCC presence showed an agreement of 82% at T1 and 84% at T2. The agreements for subtyping BCC were lower (52% for T1 and 47% for T2). The intra-rater agreement of RCM for BCC presence showed an observed agreement that varied from 79% to 92%. The observed agreements for subtyping varied from 56% to 71%.CONCLUSIONS: In conclusion, our results show that RCM is reliable in correctly diagnosing BCC based on the assessment of static RCM images. RCM could potentially play an important role in BCC management if accurate subtyping will be achieved. Therefore future clinical studies on reliability and specific RCM features for BCC subtypes are required. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
Externí odkaz: