Second malignant neoplasms in patients with non hodgkin's lymphoma
| Autor: | Pam Degendorfer, Michael Lishner, Joseph Barr, Tony Panzarella, Joyce M. Slingerland, Simon B. Sutcliffe |
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| Rok vydání: | 2006 |
| Předmět: |
Risk
Oncology Cancer Research medicine.medical_specialty Pathology Population hemic and lymphatic diseases Internal medicine medicine Carcinoma Humans Lung cancer education Survival analysis Retrospective Studies education.field_of_study business.industry Lymphoma Non-Hodgkin Incidence (epidemiology) Age Factors Neoplasms Second Primary Retrospective cohort study Hematology General Medicine medicine.disease Survival Analysis Tongue Neoplasms Non-Hodgkin's lymphoma Lymphoma Leukemia Myeloid Acute business |
| Zdroj: | Hematological Oncology. 9:169-179 |
| ISSN: | 1099-1069 0278-0232 |
| DOI: | 10.1002/hon.2900090308 |
| Popis: | A retrospective review of the records of 3886 patients with non-Hodgkin's lymphoma registered at the Princess Margaret Hospital between 1970 and 1985 was undertaken to determine the incidence of second malignant tumours. Three thousand and twenty-one patients with a minimum documented follow-up of 6 months from referral were identified for analysis. The overall observed/expected ratio for all cancers in patients with malignant lymphoma was 1, suggesting no increased risk of developing a second malignant neoplasm compared to the general population. When the data were analyzed independently for each tumour site, statistically significant increased risk of developing acute non lymphocytic leukemia (ANLL) (p less than 0.001) and carcinoma of the tongue (p less than 0.05) were found. An increased risk of lung cancer following lymphoma was detected but was not statistically significant. Survival following diagnosis of ANLL and lung cancer was similar and significantly shorter than that following the diagnosis of other second malignancies. The risk of developing a second primary cancer was significantly related to increasing patient age. |
| Databáze: | OpenAIRE |
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