Variation in causes of death in patients with non-small cell lung cancer according to stage and time since diagnosis
| Autor: | F N van Erning, Dirk De Ruysscher, Maryska L.G. Janssen-Heijnen, J.W.W. Coebergh, Harry J.M. Groen |
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| Přispěvatelé: | Radiotherapie, RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Radiotherapy, Public Health |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Time Factors PROGNOSIS NETHERLANDS causes of death Pulmonary Disease Chronic Obstructive Age Distribution AGE SDG 3 - Good Health and Well-being Carcinoma Non-Small-Cell Lung Cause of Death Internal medicine medicine Humans Registries Stage (cooking) Lung cancer non-small cell lung cancer Aged Neoplasm Staging Cause of death Aged 80 and over COPD long-term conditional survival business.industry MORTALITY Mortality rate Age Factors Cancer Hematology Middle Aged medicine.disease Comorbidity PREVALENCE respiratory tract diseases Surgery Cancer registry excess mortality Oncology Cardiovascular Diseases Female SMOKING COMORBIDITY business |
| Zdroj: | Annals of Oncology, 26(5), 902-907. Oxford University Press Annals of Oncology, 26(5), 902-907. Elsevier Ltd. |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mdv061 |
| Popis: | Background: Many patients with non-small cell lung cancer (NSCLC) die within the first few years of diagnosis, and considerable excess mortality remains even after 5 years. We investigated the death rate and the distribution of causes of death for NSCLC patients by age and stage at diagnosis during long-term follow-up.Patients and methods: All 72 021 patients aged 45-89 years diagnosed with stage I-III NSCLC between 1989 and 2008 in the Netherlands and who died up till 2011 were derived from the Netherlands Cancer Registry and linked with the database of Statistics Netherlands for underlying causes of death. Mortality ratios and proportional distribution of causes of death were calculated during 5 time periods after diagnosis of NSCLC (up to 15 years).Results: Median follow-up was 9.6 years (range: 0-23 years). Lung cancer was the predominant cause of death in the first 6 years after diagnosis (being 80%-85% and similar to 90% up to 3 years for localized and locally advanced disease, respectively, and similar to 60%-75% and similar to 75%-85% during years 4-6 for both stage groups, respectively). Thereafter, lung cancer as cause of death proportionally decreased with time since diagnosis, but remained over 30%. Hence, cardiovascular diseases and chronic obstructive pulmonary diseases (COPD) became more important causes of death, especially for patients aged >60 years at diagnosis (up to 34% for cardiovascular diseases and up to 19% for COPD).Conclusions: With time, the relative contribution of cardiovascular and COPD causes of death increased, although the absolute contribution of lung cancer remained high in non-metastatic NSCLC. Therefore, managing morbidity of these diseases remains relevant. |
| Databáze: | OpenAIRE |
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