Gingival Carcinogenicity in Female Harlan Sprague-Dawley Rats following Two-Year Oral Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Dioxin-Like Compounds
| Autor: | Abraham Nyska, Donald M. Sells, Micheal P. Jokinen, Denise Orzech, Nigel J. Walker, Tiwanda Marsh, Michael E. Wyde, Amy E. Brix, Katsuhiko Yoshizawa, Joseph K. Haseman |
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| Rok vydání: | 2004 |
| Předmět: |
Molar
medicine.medical_specialty Oral treatment Polychlorinated Dibenzodioxins Time Factors Carcinogenicity Tests Gingiva Junctional epithelium Administration Oral Dioxins Toxicology Rats Sprague-Dawley Internal medicine Sprague dawley rats Animals Medicine heterocyclic compounds Chronic toxicity Carcinogen Benzofurans Gingival Neoplasms Hyperplasia Dose-Response Relationship Drug business.industry Drug Synergism medicine.disease Polychlorinated Biphenyls Tetrachlorodibenzo-p-dioxin Rats stomatognathic diseases Endocrinology Carcinoma Squamous Cell Female business |
| Zdroj: | Toxicological Sciences. 83:64-77 |
| ISSN: | 1096-0929 |
| DOI: | 10.1093/toxsci/kfi016 |
| Popis: | We evaluated gingival toxicities induced by chronic exposure of female Harlan Sprague-Dawley rats to dioxin and dioxin-like compounds (DLCs) and compared them to similarly induced oral lesions reported in the literature. This investigation represents part of an ongoing initiative of the National Toxicology Program to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated dioxins, furans, and biphenyls. For two years, animals were administered by gavage 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); 3,3',4,4',5-pentachlorobiphenyl (PCB126); 2,3,4,7,8-pentachlorodibenzofuran (PeCDF); 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153); a tertiary mixture of TCDD, PCB126, and PeCDF; a binary mixture of PCB126 and 153; or a binary mixture of PCB126 and 2,3',4,4',5-pentachlorobiphenyl (PCB118); control animals received corn oil-acetone vehicle (99:1) alone. A full complement of tissues, including the palate with teeth, was examined microscopically. In the groups treated with TCDD and the mixtures of TCDD, PCB126, and PeCDF; PCB126 and 153; and PCB126 and 118, the incidences of gingival squamous hyperplasia increased significantly. Moreover, in the groups treated with TCDD, PCB126, and the mixture of PCB126 and 153, squamous cell carcinoma (SCC) in the oral cavity increased significantly. This investigation constitutes the first report documenting that chronic administration of dioxin-like PCBs can induce gingival SCC in rats. These results indicate that dioxin and DLCs target the gingiva of the oral cavity, in particular the junctional epithelium of molars. |
| Databáze: | OpenAIRE |
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