Autor: |
Aaron B. Miller, Harry B. Marr, Katrina L. Creech, G. Bruce Wisely, Shawn P. Williams, Adwoa Akwabi-Ameyaw, Lihong Chen, David N. Deaton, Justin A. Caravella, Paul Kenneth Spearing, Kevin P. Madauss, Derek J. Parks, Frank Navas, Dan Todd |
Rok vydání: |
2011 |
Předmět: |
|
Zdroj: |
Bioorganicmedicinal chemistry letters. 21(20) |
ISSN: |
1464-3405 |
Popis: |
To further explore the optimum placement of the acid moiety in conformationally constrained analogs of GW 4064 1a, a series of stilbene replacements were prepared. The benzothiophene 1f and the indole 1g display the optimal orientation of the carboxylate for enhanced FXR agonist potency. |
Databáze: |
OpenAIRE |
Externí odkaz: |
|