Clinical significance of cytogenetic changes in childhood T-cell acute lymphoblastic leukemia: results of the multicenter group Moscow-Berlin (MB)
| Autor: | Dmitry Mercur’ev, Eugenia Aprelova, Gesche Tallen, Ludmila Baidun, Elena Zerkalenkova, Julia Rumiantseva, Alexander Karachunskii, Alexander Rumiantsev, Svetlana Lagoiko, Olga Soldatkina, Tatiana Gindina, Oleg Bydanov, Olga Plekhanova, Anna Kazakova, Yulia Olshanskaya, Guenter Henze, Ildar Barhkatov, Grigory Tsaur |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Adolescent Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Humans Clinical significance Child In Situ Hybridization Fluorescence Chromosome Aberrations Gene Rearrangement business.industry Incidence Infant Karyotype Hematology Prognosis Childhood T-Cell Acute Lymphoblastic Leukemia 030220 oncology & carcinogenesis Child Preschool Karyotyping Fish Female business Biomarkers 030215 immunology |
| Zdroj: | Leukemialymphoma. 60(2) |
| ISSN: | 1029-2403 |
| Popis: | The prognostic significance of genetic lesions in T-cell ALL still needs to be elucidated. Karyotyping and FISH were performed in samples from 120 patients with T-cell ALL registered in the trial Moscow-Berlin 2008. Most frequent rearrangements were TLX3 (N = 29; 24%) and TAL1 (N = 18; 15%), followed by KMT2A (N = 6; 5%), TLX1 (N = 5; 4.2%), and 11p13-15 (N = 5; 4.2%). In 16.7% of patients, the karyotype was normal, and in 30.8% 'other' aberrations were seen. Patients with a normal karyotype, TAL1, or KMT2A rearrangements had the most favorable outcome (probability of event free survival (pEFS): 82% ± 6%), while prognosis for patients with TLX3 and TLX1 rearrangements and 'other' aberrations was less favorable (pEFS: 62% ± 6%). Worst outcome was observed for five patients with 11p rearrangements (pEFS: 20% ± 18%). In summary, three subgroups of patients with T-cell ALL with significantly different outcomes could be defined by cytogenetic profiling. |
| Databáze: | OpenAIRE |
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