Changes in body composition and mitochondrial nucleic acid content in patients switched from failed nucleoside analogue therapy to ritonavir-boosted indinavir and efavirenz
| Autor: | Peter Reiss, Somjai Wangsuphachart, Matthew Law, Praphan Phanuphak, Sakalaya Lerdlum, David A. Cooper, Preeyaporn Srasuebkul, Anchali Krisanachinda, Kiat Ruxrungtham, Joep M. A. Lange, Mark A. Boyd, Andrew Carr, Darl D. Bien |
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| Přispěvatelé: | Infectious diseases, Global Health |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Efavirenz RNA Mitochondrial Adipose tissue Indinavir Biology DNA Mitochondrial chemistry.chemical_compound Absorptiometry Photon Internal medicine medicine Immunology and Allergy Humans Treatment Failure Lipoatrophy Acquired Immunodeficiency Syndrome Lumbar Vertebrae Ritonavir Nucleoside analogue Triglyceride HIV Protease Inhibitors Middle Aged Viral Load medicine.disease Mitochondria Stavudine Infectious Diseases Endocrinology Treatment Outcome chemistry Body Composition RNA RNA Viral Reverse Transcriptase Inhibitors Lipodystrophy Tomography X-Ray Computed Zidovudine medicine.drug |
| Zdroj: | Journal of infectious diseases, 194(5), 642-650. Oxford University Press |
| ISSN: | 0022-1899 |
| Popis: | Background. Body composition changes complicate antiretroviral therapy. Improvements in lipoatrophy after a switch in nucleoside reverse-transcriptase inhibitors (NRTIs) have been demonstrated. We investigated 60 patients switching from failed NRTIs to ritonavir-boosted indinavir and efavirenz. Methods. Body composition (assessed by dual-energy x-ray absorptiometry scan and by single-slice computed tomography of the abdomen through the level of the fourth lumbar vertebra [L4] and the mid-right thigh) and fasted metabolics were measured at the baseline time-point at switch and at weeks 48 and 96 thereafter. Mitochondrial DNA and RNA were extracted from right-thigh subcutaneous fat and peripheral-blood mononuclear cells (PBMCs) at weeks 0 and 48. The primary end point was the change in mean limb fat over 48 weeks. Results. At week 96, we observed increases in mean (standard deviation [SD]) limb fat (+620 [974] g; P = .003), L4 subcutaneous adipose tissue (+20 [35] cm 2 ; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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