Studies ofPanax japonicusFibrinolysis
| Autor: | Hidemi Shiomoto, Keiichi Samukawa, Seiya Fukuda, Michinori Kubo, Tong Chun-ning, Hideaki Matsuda |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_treatment Panax Pharmaceutical Science Pharmacology Biology Analytical Chemistry In vivo Drug Discovery Fibrinolysis Euglobulin lysis time medicine Animals Disseminated intravascular coagulation Urokinase Plants Medicinal Traditional medicine Plant Extracts Organic Chemistry Rats Inbred Strains Biological activity Saponins medicine.disease In vitro Rats Complementary and alternative medicine Coagulation Molecular Medicine Drugs Chinese Herbal medicine.drug |
| Zdroj: | Planta Medica. 55:18-21 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | The effects of a 70% methanol extract (PMe) obtained from the rhizomes of Panax japonicus C. A. Meyer on experimental thrombosis and fibrinolysis were investigated in vivo and in vitro. PMe showed a promotive effect on the activation of the fibrinolytic system as determined by the euglobulin lysis time (ELT) assay but was inactive to the inhibitory effect against endotoxin-induced disseminated intravascular coagulation (DIC) in rats. PMe and its major components, chikusetsusaponin III, IV, and V, strongly promoted the action of urokinase in fibrin plate. These results suggested that PMe promotes the fibrinolysis and its effective components are chikusetsusaponin III, IV, and V. |
| Databáze: | OpenAIRE |
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