Mechanical on-off gates for regulation of drug release in cutaneous or musculoskeletal tissue repairs
| Autor: | Chunyu Qian, Jia Yu, Wenguo Cui, Lili Liu, Huitong Ruan, Kun Xi, Chao Gao, Wei Liangyi, Zong-Ping Luo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
Materials science Drug Compounding Composite number Ibuprofen Bioengineering Microbial Sensitivity Tests 02 engineering and technology engineering.material 010402 general chemistry Proof of Concept Study 01 natural sciences Biomaterials Coating Musculoskeletal tissue Animals Cells Cultured Skin 021001 nanoscience & nanotechnology Controlled release Electrospinning Biomechanical Phenomena Rats 0104 chemical sciences Disease Models Animal Mechanics of Materials Delayed-Action Preparations Doxycycline engineering Drug release Adhesive 0210 nano-technology Drug carrier Biomedical engineering |
| Zdroj: | Materials Science and Engineering: C. 115:111048 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2020.111048 |
| Popis: | Drug release synchronized with tissue motion is attractive to cutaneous or musculoskeletal tissue injury repair. Here, we have developed a method of regulating drug release by mechanical on-off gates for potential treatment of repeated injury in these tissues. The mechanical gates consisted of a multilayer structure: A brittle outmost layer adhered to an elastic middle layer, which wrapped an inmost drug carrier to form the composite multilayer structure. When it was stretched, cracks appeared as mechanical gates due to mechanical performance difference between the outmost layer and the middle layer, leading to the drug release. When the external force disappeared, it recovered to stop the drug release. The controlled drug release would therefore be achieved by changing the status (opening or closure) of mechanical gates through applying this on-off mechanical stretching. A prototype based on the composite multilayer structure of adhesive coating and electrospinning technique realized the controlled release of drug and effectively repaired the incision. More types of composite multilayer structures for mechanical drug release were expected to meet curing requirement in cutaneous or musculoskeletal tissues. |
| Databáze: | OpenAIRE |
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