Science based guidance for the assessment of endocrine disrupting properties of chemicals
| Autor: | Nina Hallmark, Grace H. Panter, Lennart Weltje, James R. Wheeler, Ivana Fegert, Remi Bars, Melanie Gross, Dick Lewis, Arnd Weyers, Fabrice Broeckaert, Malyka Galay-Burgos, Tim Kedwards, Sue O’Hagan |
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| Rok vydání: | 2011 |
| Předmět: |
Weight of evidence
Task force Advisory Committees International Agencies Guidelines as Topic Context (language use) General Medicine Endocrine Disruptors Ecotoxicology Toxicology Directive Risk Assessment Hazard Europe Risk analysis (engineering) Chemical products Toxicity Tests Government Regulation Animals Humans Endocrine system Business |
| Zdroj: | Regulatory Toxicology and Pharmacology. 59:37-46 |
| ISSN: | 0273-2300 |
| DOI: | 10.1016/j.yrtph.2010.09.003 |
| Popis: | The European legislation on plant protection products (Regulation (EC) No. 1107/2009) and biocides (Directive 98/8/EC), as well as the regulation concerning chemicals (Regulation (EC) No. 1907/2006 ‘REACH’) only support the marketing and use of chemical products on the basis that they do not induce endocrine disruption in humans or non-target species. However, there is currently no agreed guidance on how to identify and evaluate endocrine activity and disruption. Consequently, an ECETOC task force was formed to provide scientific criteria that may be used within the context of these three legislative documents. Specific scientific criteria for the determination of endocrine disrupting properties that integrate information from both regulatory (eco)toxicity studies and mechanistic/screening studies are proposed. These criteria combine the nature of the adverse effects detected in studies which give concern for endocrine toxicity with an understanding of the mode of action of toxicity so that adverse effects can be explained scientifically. The criteria developed are presented in the form of flow charts for assessing relevant effects for both humans and wildlife species. In addition, since not all chemicals with endocrine disrupting properties are of equal hazard, assessment of potency is also proposed to discriminate chemicals of high concern from those of lower concern. The guidance presented in this paper includes refinements made to an initial proposal following discussion of the criteria at a workshop of invited regulatory, academic and industry scientists. |
| Databáze: | OpenAIRE |
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